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Pyronaridine exhibits antibiotic properties and is clinically used for its antimalarial and anti-parasitic activities against Plasmodium. Pyronaridine inhibits β-hematin formation, binding hematin and preventing glutathione-dependent degradation.
| Cas No. | 76748-86-2 |
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| Purity | ≥98% |
| Formula | C29H32ClN5O2 • 4H3PO4 |
| Formula Wt. | 910.03 |
| Chemical Name | 4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol tetraphosphate |
| IUPAC Name | 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1, 5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2, 5-dien-1-one;phosphoric acid |
| Synonym | Malaridine |
| Melting Point | 233-236°C |
| Solubility | Soluble in water. Very sparingly soluble in ethanol. |
| Appearance | Yellow Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Henrich PP, O'Brien C, Sáenz FE, et al. Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model. Antimicrob Agents Chemother. 2014 Jan;58(1):183-95. PMID: 24145526.
Kritsiriwuthinan K, Chaotheing S, Shaw PJ, et al. Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine. Malar J. 2011 Aug 18;10:242. PMID: 21849091.
Auparakkitanon S, Chapoomram S, Kuaha K, et al. Targeting of hematin by the antimalarial pyronaridine. Antimicrob Agents Chemother. 2006 Jun;50(6):2197-200. PMID: 16723583.