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Pyronaridine Tetraphosphate

Pyronaridine Tetraphosphate

Product ID P9768
Cas No. 76748-86-2
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $97.70 In stock
100 mg $157.80 In stock
250 mg $277.90 In stock
1 g $646.10 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Pyronaridine exhibits antibiotic properties and is clinically used for its antimalarial and anti-parasitic activities against Plasmodium. Pyronaridine inhibits β-hematin formation, binding hematin and preventing glutathione-dependent degradation.

Product Info

Cas No.

76748-86-2

Purity

≥98%

Formula

C29H32ClN5O2 • 4H3PO4

Formula Wt.

910.03

Chemical Name

4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol tetraphosphate

IUPAC Name

4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1, 5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2, 5-dien-1-one;phosphoric acid

Synonym

Malaridine

Melting Point

233-236°C

Solubility

Soluble in water. Very sparingly soluble in ethanol.

Appearance

Yellow Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

P9768 MSDS PDF

Info Sheet

P9768 Info Sheet PDF

References

Henrich PP, O'Brien C, Sáenz FE, et al. Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model. Antimicrob Agents Chemother. 2014 Jan;58(1):183-95. PMID: 24145526.

Kritsiriwuthinan K, Chaotheing S, Shaw PJ, et al. Global gene expression profiling of Plasmodium falciparum in response to the anti-malarial drug pyronaridine. Malar J. 2011 Aug 18;10:242. PMID: 21849091.

Auparakkitanon S, Chapoomram S, Kuaha K, et al. Targeting of hematin by the antimalarial pyronaridine. Antimicrob Agents Chemother. 2006 Jun;50(6):2197-200. PMID: 16723583.

Custom Order

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