Description
Quinacrine exhibits anti-parasitic, anti-protozoan, anticancer, and anti-inflammatory activities. Quinacrine alters cell membrane permeability and is clinically used to treat infections of Giardia. In colon cancer cells, quinacrine induces apoptosis, activates p53 and p21, and inhibits topoisomerase. In other cellular models, quinacrine decreases TNF-α, IL-1β, and CCL21 production, suppresses migration of dendritic cells, and inhibits activation of CD8+ T cells.