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Rabeprazole is a proton pump inhibitor (PPI) that exhibits antacid activity, as it is clinically used to treat gastric ulcers and gastroesophageal reflux disease (GERD). Rabeprazole binds cysteine residues on the H+/K+ ATPase, inhibiting gastric acid secretion. Additionally, rabeprazole displays some neuroprotective potential, as it inhibits human small C-terminal domain phosphatases (Scpc), modulating expression of neuronal genes and neuronal stem cell differentiation in vitro.
| Cas No. | 117976-90-6 |
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| Purity | ≥98% |
| Formula | C18H20N3O3S Na |
| Formula Wt. | 381.42 |
| Chemical Name | 2[[[4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole |
| IUPAC Name | sodium;2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl] benzimidazol-1-ide |
| Synonym | Pariprazole |
| Melting Point | 99-100°C |
| Solubility | Insoluble in water. Soluble in DMSO. |
| Appearance | Yellowish off-white crystal powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Ward RM, Kearns GL. Proton pump inhibitors in pediatrics : mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics. Paediatr Drugs. 2013 Apr;15(2):119-31. PMID: 23512128.
Zhang M, Cho EJ, Burstein G, et al. Selective inactivation of a human neuronal silencing phosphatase by a small molecule inhibitor. ACS Chem Biol. 2011 May 20;6(5):511-9. PMID: 21348431.
Sanaka M, Anjiki H, Yamamoto T, et al. Rabeprazole delays gastric emptying of a nutrient liquid. J Gastroenterol Hepatol. 2007 Nov;22(11):1806-9. PMID: 17914954.