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Rapamycin

Rapamycin

Product ID R0161
Cas No. 53123-88-9
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $48.20 In stock
10 mg $147.20 In stock
25 mg $293.20 In stock
100 mg $638.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Rapamycin is a macrolide initially produced by Streptomyces that exhibits immunosuppressive and pro-fibrotic activities. Rapamycin inhibits mTOR by binding FKBP12 and forming a complex that binds directly to mTOR; it is clinically used to prevent rejection in organ transplant patients. Rapamycin prevents IL-2-induced activation of T cells and B cells. Rapamycin also prevents IgA nephropathy, decreasing IgA deposition, inhibiting cell proliferation, and suppressing expression of α-SMA, type III collagen, PDGF, and TGF-β1. Additionally, rapamycin increases connective tissue growth factor levels in epithelial cells.

Product Info

Cas No.

53123-88-9

Purity

≥99%

Formula

C51H79NO13

Formula Wt.

914.17

Chemical Name

Sirolimus

IUPAC Name

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone

Synonym

Sirolimus, Sirolimusum, Rapamune, AY-22989

Melting Point

183-185°C

Solubility

Soluble in ether, chloroform, acetone, methanol, DMF, DMSO (20 mg/mL), and ethanol (up to 2 mM). Sparingly soluble in hexane and petr ether. Insoluble in water.

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

R0161 MSDS PDF

Info Sheet

R0161 Info Sheet PDF

Brochures

Rapamycin Flyer

References

Jiang Z, He Q, Wezeman J, et al. A cocktail of rapamycin, acarbose, and phenylbutyrate prevents age-related cognitive decline in mice by targeting multiple pathways. Geroscience. 2024 Oct;46(5):4855-4868. PMID: 38755466.

Klintmalm GB, Nashan B. The Role of mTOR Inhibitors in Liver Transplantation: Reviewing the Evidence. J Transplant. 2014;2014:845438. PMID: 24719752.

Tian J, Wang Y, Zhou X, et al. Rapamycin slows IgA nephropathy progression in the rat. Am J Nephrol. 2014;39(3):218-29. PMID: 24603476.

Xu X, Wan X, Geng J, et al. Rapamycin regulates connective tissue growth factor expression of lung epithelial cells via phosphoinositide 3-kinase. Exp Biol Med (Maywood). 2013 Sep;238(9):1082-94. PMID: 23986222.

Custom Order

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