LKT Labs

Biochemicals for Life Science Research

Rebaudioside A

Rebaudioside A

Product ID R162041
Cas No. 58543-16-1
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $140.00 In stock
250 mg $300.00 In stock
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Description

Rebaudioside A is a steviol glycoside found in stevia leaves and used as a high-potency sucrose substitute. Rebaudioside A has been found to stimulate the release of gut peptides and enhance enteroendocrine cell differentiation in mouse small intestine organoids. Experimental determination showed that long-term treatment of C57BL6/J mice with rebaudioside A did not increase weight gain, alter insulin action, or disrupt circadian rhythms. Furthermore, chemically induced epilepsy in rats showed a dose-dependent decrease in spiking in epileptiform activity in the rats treated with rebaudioside A.

Product Info

Cas No.

58543-16-1
Purity

≥98%
Formula

C44H70O23
Formula Wt.

967.02
Chemical Name

[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxan-2-yl]oxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate
IUPAC Name

[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,4S,5R,9S,10R,13S)-13-[(2S,3R,4S,5R,6R)-5-hydroxy-6-(hydroxymethyl)-3,4-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxan-2-yl]oxy-5,9-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylate
Synonym

Rebaudiana A, Stevioside A3, Truvia
Melting Point

242-244

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

R162041 MSDS PDF
Info Sheet

R162041 Info Sheet PDF

References

Gallo M, Vitulano M, Andolfi A, et al. Rapid solid-liquid dynamic extraction (RSLDE): a new rapid and greener method for extracting two steviol glycosides (stevioside and rebaudioside A) form stevia leaves. Plant Foods Hum Nutr. 2017 Jun;72(2):141-148. PMID: 28108883.

van der Wielen N, Ten Klooster JP, Muckenschnabl S, et al. The noncaloric sweetener rebaudioside A stimulates glucagon-like peptide 1 release and increases enteroendocrine cell numbers in 2-dimensional mouse organoids derived from different locations of the intestine. J Nutr. 2016 Dec;146(12):2429-2435. PMID: 27798332.

Reynolds TH, Soriano RA, Obadi OA, et al. Long term rebaudioside A treatment does not alter circadian activity rhythms, adiposity, or insulin action in male mice. PLoS One. 2017 May 5;12(5):e0177138. PMID: 28475596.

Uyanikgil Y, Cavusoglu T, Balcioglu HA, et al. Rebaudioside A inhibits pentylenetetrazol-induced convulsions in rats. Kaohsiung J Med Sci. 2016 Sep;32(9):446-451. PMID: 27638403.

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