• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Reveromycin A

Reveromycin A

Product ID R1985
Cas No. 134615-37-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $324.50 In stock
5 x 100 µg $1,297.90 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Reveromycin A is an osteoclast-targeting antibiotic compound that exhibits anti-resorptive and antifungal activities. In animal models of juvenile Paget’s disease, reveromycin A inhibits bone resorption and normalizes bone turnover and formation. Reveromycin A inhibits isoleucyl-tRNA synthase, preventing protein synthesis in osteoclasts; this induces apoptosis and prevents resorption in vivo. Additionally, reveromycin A inhibits bone metastasis by lung cancer cells.

Product Info

Cas No.

134615-37-5

Purity

≥98%

Formula

C36H52O11

Formula Wt.

660.79

Chemical Name

Butanedioic acid, mono(3-butyl-8-(9-carboxy-6- hydroxy-3,7-dimethyl-2,4,8-nonatrienyl)-2-(4-carboxy-3-methyl-1,3-butadienyl)-9-methyl-1,7-dioxaspiro(5.5)undec-3-yl) ester

IUPAC Name

(2E,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-2-[(1E, 3E)-4-carboxy-3-methylbuta-1, 3-dienyl]-3-(3-carboxypropanoyloxy)-9-methyl-1, 7-dioxaspiro[5.5]undecan-8-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid

Melting Point

95°C

Solubility

Soluble in DMF, DMSO, ethanol, ethyl acetate or methanol.

Appearance

Tan Lyophilisate

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R1985 MSDS PDF

Info Sheet

R1985 Info Sheet PDF

References

Yabumoto T, Miyazawa K, Tabuchi M, et al. Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice. Am J Orthod Dentofacial Orthop. 2013 Sep;144(3):368-80. PMID: 23992809.

Hiraoka K, Zenmyo M, Watari K, et al. Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages. Cancer Sci. 2008 Aug;99(8):1595-602. PMID: 18754872.

Woo JT, Kawatani M, Kato M, et al. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4729-34. PMID: 16537392.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B4402

    Blasticidin S Hydrochloride

    Protein translation inhibitor.

    ≥98%
  • O0829

    Ochratoxin A

    Mycotoxin produced by Aspergillus and Penicillu...

    ≥98%
  • E6880

    Erucin

    Isothiocyanate found in cruciferous vegetables,...

    ≥98%
  • N7200

    NS-11394

    GABA-A α5/3/2 positive modulator.

    ≥98%
  • S7600

    Staurosporine

    Alkaloid produced by Streptomyces, precursor in...

    ≥98%
  • L5624

    Loganin

    Iridoid glucoside found in Cornus officialis; Î...

    ≥98%
  • A7657

    Atosiban Acetate

    Peptide, alters uterine contractility; V1/2 and...

    ≥95%
  • D1621

    Deferasirox

    Iron chelator.

    ≥99%
  • A5032

    D,L-Aminoglutethimide

    Aromatase inhibitor.

    ≥98%
  • K0133

    Kainic Acid

    Excitatory amino acid found in seaweed; AMPA an...

    ≥98%
  • T5869

    Torcetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • O0830

    Ochratoxin B

    Non-chlorinated analogue of the mycotoxin Ochra...

    ≥99%
  • G0181

    Gastrin Releasing Peptide, human

    Endogenous bombesin-like peptide, involved in f...

    ≥95%
  • B011460

    Baloxavir Marboxil

    Cap-dependent endonuclease inhibitor

    ≥ 99%
  • G5322

    GNF-5

    Abl inhibitor.

    ≥99%
  • C4517

    Clenbuterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • T7056

    Troglitazone

    Thiazolidinedione; PPARγ agonist, ATP-sensitiv...

    ≥97%
  • R0110

    Ractopamine Hydrochloride

    β1/2-adrenergic agonist.

    ≥97%
  • R5894

    Roxatidine Acetate Hydrochloride

    Histamine H2 antagonist.

    ≥98%
  • N5770

    Norfloxacin Hydrochloride

    First generation fluoroquinolone antibiotic.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only