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Reveromycin A

Reveromycin A

Product ID R1985
Cas No. 134615-37-5
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $324.50 In stock
5 x 100 µg $1,297.90 Please Inquire
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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Reveromycin A is an osteoclast-targeting antibiotic compound that exhibits anti-resorptive and antifungal activities. In animal models of juvenile Paget’s disease, reveromycin A inhibits bone resorption and normalizes bone turnover and formation. Reveromycin A inhibits isoleucyl-tRNA synthase, preventing protein synthesis in osteoclasts; this induces apoptosis and prevents resorption in vivo. Additionally, reveromycin A inhibits bone metastasis by lung cancer cells.

Product Info

Cas No.

134615-37-5

Purity

≥98%

Formula

C36H52O11

Formula Wt.

660.79

Chemical Name

Butanedioic acid, mono(3-butyl-8-(9-carboxy-6- hydroxy-3,7-dimethyl-2,4,8-nonatrienyl)-2-(4-carboxy-3-methyl-1,3-butadienyl)-9-methyl-1,7-dioxaspiro(5.5)undec-3-yl) ester

IUPAC Name

(2E,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-2-[(1E, 3E)-4-carboxy-3-methylbuta-1, 3-dienyl]-3-(3-carboxypropanoyloxy)-9-methyl-1, 7-dioxaspiro[5.5]undecan-8-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid

Melting Point

95°C

Solubility

Soluble in DMF, DMSO, ethanol, ethyl acetate or methanol.

Appearance

Tan Lyophilisate

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R1985 MSDS PDF

Info Sheet

R1985 Info Sheet PDF

References

Yabumoto T, Miyazawa K, Tabuchi M, et al. Stabilization of tooth movement by administration of reveromycin A to osteoprotegerin-deficient knockout mice. Am J Orthod Dentofacial Orthop. 2013 Sep;144(3):368-80. PMID: 23992809.

Hiraoka K, Zenmyo M, Watari K, et al. Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages. Cancer Sci. 2008 Aug;99(8):1595-602. PMID: 18754872.

Woo JT, Kawatani M, Kato M, et al. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4729-34. PMID: 16537392.

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