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Ribavirin is a purine nucleoside derivative that exhibits antiviral and anti-inflammatory activities. This compound displays broad spectrum antiviral activity but is most often clinically used in conjunction with IFN to treat hepatitis C infection. In macrophages, ribavirin decreases NO levels.
| Cas No. | 36791-04-5 |
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| Purity | ≥98% |
| Formula | C8H12N4O5 |
| Formula Wt. | 244.21 |
| Chemical Name | 1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide |
| IUPAC Name | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2, 4-triazole-3-carboxamide |
| Synonym | Copegus, Ribamidil, RTCA, Varazid, Virazole |
| Melting Point | 166-168°C |
| Solubility | Soluble in water (20 mg/mL), DMSO (49 mg/mL). |
| Appearance | White Crystal Powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Pinilla-Macua I, Fernández-Calotti P, Pérez-Del-Pulgar S, et al. Ribavirin Uptake into Human Hepatocyte HHL5 Cells Is Enhanced by Interferon-α via up-Regulation of the Human Concentrative Nucleoside Transporter (hCNT2). Mol Pharm. 2014 Sep 2;11(9):3223-30. PMID: 24957263.
Parekh PJ, Shiffman ML. The role of interferon in the new era of hepatitis C treatments. Expert Rev Gastroenterol Hepatol. 2014 Aug;8(6):649-56. PMID: 24758387.
Wohl BM, Smith AA, Kryger MB, et al. Narrow therapeutic window of ribavirin as an inhibitor of nitric oxide synthesis is broadened by macromolecular prodrugs. Biomacromolecules. 2013 Nov 11;14(11):3916-26. PMID: 24156371.