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Risedronic Acid

Risedronic Acid

Product ID R3374
Cas No. 105462-24-6
Purity ≥97%
Product Unit SizeCostQuantityStock
25 mg $61.10 In stock
100 mg $142.90 In stock
250 mg $377.90 In stock
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  • Product Info
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  • Description
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Description

Risedronic acid is a bisphosphonate clinically used to strengthen bone; it exhibits anti-osteoporotic, anti-inflammatory, antinociceptive, anti-parasitic, and antibiotic activities. Risedronic acid inhibits bone marrow adipogenesis and suppresses RANKL expression in vivo. In vivo, risedronic acid displays antimalarial activity, inhibiting the transfer of farnesyl phosphate to Plasmodium proteins and preventing parasitic growth in vivo. Additionally, risedronic acid inhibits release of TNF-α and leukotriene B4 (LTB4), decreasing inflammatory cell infiltration in vivo. In other animal models, risedronic acid inhibits chemically-induced pain.

Product Info

Cas No.

105462-24-6

Purity

≥97%

Formula

C7H11NO7P2

Formula Wt.

283.11

Chemical Name

[1-Hydroxy-2-(3-pyridinyl)ethylidene]bisphosphonic acid

IUPAC Name

(1-hydroxy-1-phosphono-2-pyridin-3-ylethyl)phosphonic acid

Synonym

Risedronate

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

R3374 MSDS PDF

Info Sheet

R3374 Info Sheet PDF

References

Jin J, Wang L, Wang XK, et al. Risedronate inhibits bone marrow mesenchymal stem cell adipogenesis and switches RANKL/OPG ratio to impair osteoclast differentiation. J Surg Res. 2013 Mar;180(1):e21-9. PMID: 22487394.

Jordão FM, Saito AY, Miguel DC, et al. In vitro and in vivo antiplasmodial activities of risedronate and its interference with protein prenylation in Plasmodium falciparum. Antimicrob Agents Chemother. 2011 May;55(5):2026-31. PMID: 21357292.

Carvalho AP, Bezerra MM, Girão VC, et al. Anti-inflammatory and anti-nociceptive activity of risedronate in experimental pain models in rats and mice. Clin Exp Pharmacol Physiol. 2006 Jul;33(7):601-6. PMID: 16789926.

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