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AM1241 is a selective cannabinoid receptor 2 (CB2) agonist. It demonstrates activity in multiple pain murine models. AM1241 was used to treat osteopathic carcinoma pain in mice. AM1241 decreased allodynia found in a rodent model, and also decreased thermal hyperalgesia. AM1241 was used in a murine Parkinson’s disease model, where it increased expression of Parkin and PINK1, and also stimulated neurogenesis.
| Cas No. | 444912-48-5 |
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| Purity | ≥96% |
| Formula | C22H22IN3O3 |
| Formula Wt. | 503.34 |
| Chemical Name | (2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
| IUPAC Name | (2-iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone |
| Synonym | AM1241 |
| Solubility | Soluble in DMSO to 10 mM and in ethanol to 10 mM |
| Appearance | Yellow powder |
| Store Temp | -20°C |
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| Ship Temp | Blue Ice |
| MSDS | |
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| Info Sheet |
Shi J, Cai Q, Zhang J et al. AM1241 alleviates MPTP-induced Parkinsons’s disease and promotes the regeneration of DA neurons in PD mice. Oncotarget. 2017 Jun 29;8(40):67837-67850. PMID: 28978077.
Curto-Reyes V, Llames S, Hidalgo A et al. Spinal and peripheral analgesic effects of the CB2 cannabinoid receptor agonist AM1241 in two models of bone cancer-induced pain. Br J Pharmacol. 2010 Jun;160(3):561-73. PMID: 20233215.
Ibrahim MM, Deng H, Zvonok A et al. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci USA. 2003 Sep 2;100(18):10529-33. PMID: 12917492.