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S-(−)-Schisandrin B

S-(−)-Schisandrin B

Product ID S0831
Cas No. 61281-37-6
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $201.40 In stock
10 mg $330.00 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Schisandrin B is found in Schisandra; it exhibits anti-fibrotic, anti-inflammatory, cardioprotective, hepatoprotective, neuroprotective, and anti-metastatic activities. In vitro, schisandrin B decreases TGF-β1-induced myosin light chain phosphorylation and Smad signaling, preventing stress fiber formation. In animal models of myocardial infarction, schisandrin B downregulates expression of pro-inflammatory cytokines and inhibits myocardial apoptosis, decreasing infarct size and improving heart function and survival rates. Schisandrin B also increases expression of HSP27 and HSP70, inhibiting acetaminophen-induced liver injury and hepatic necrosis. In animal models of cerebral ischemia/reperfusion, this compound decreases expression of IL-1β and TNF-α and prevents degradation of matrix metalloproteinases 2 and 9 (MMP2/9), decreasing infarct volume. Additionally, schisandrin B inhibits invasion of breast cancer cells by suppressing the epithelial to mesenchymal transition (EMT), increasing survival rates in vivo.

Product Info

Cas No.

61281-37-6

Purity

≥98%

Formula

C23H28O6

Formula Wt.

400.47

Chemical Name

Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole, 5,6,7,8- tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, stereoisomer

IUPAC Name

3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaene

Synonym

γ-Schisandrin, S(-) Wuweizisu B, S(-) Schizandrin B

Melting Point

100-102°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S0831 MSDS PDF

Info Sheet

S0831 Info Sheet PDF

References

Chun JN, Kim SY, Park EJ, et al. Schisandrin B suppresses TGFβ1-induced stress fiber formation by inhibiting myosin light chain phosphorylation. J Ethnopharmacol. 2014 Mar 14;152(2):364-71. PMID: 24486209.

Li L, Zhang T, Zhou L, et al. Schisandrin B attenuates acetaminophen-induced hepatic injury through heat-shock protein 27 and 70 in mice. J Gastroenterol Hepatol. 2014 Mar;29(3):640-7. PMID: 24219791.

Chen P, Pang S, Yang N, et al. Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction. PLoS One. 2013 Nov 8;8(11):e79418. PMID: 24260217.

Lee TH, Jung CH, Lee DH. Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats. Food Chem Toxicol. 2012 Dec;50(12):4239-45. PMID: 22960133.

Liu Z, Zhang B, Liu K, et al. Schisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transition. PLoS One. 2012;7(7):e40480. PMID: 22848381.

Custom Order

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