• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Sanguinarine Chloride

Sanguinarine Chloride

Product ID S0254
Cas No. 5578-73-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $126.20 In stock
25 mg $449.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Sanguinarine is a benzophenanthridine alkaloid that exhibits a wide variety of beneficial properties, including anticancer, anti-inflammatory, and antibacterial activities. In breast cancer cells, sanguinarine increases levels of tissue inhibitor of metalloproteinase 1 and 2 (TIMP1 and TIMP2) and heme-oxygenase 1 (HO-1), decreases expression of matrix metalloproteinases (MMPs), prostaglandin E2 (PGE2), and COX-2, and inhibits the phosphorylation of Akt and ERK as well as the activation of NF-κB. Sanguinarine also inhibits VEGF release and increases levels of ROS, inducing apoptosis and inhibiting growth of mammary adenocarcinoma cells. In animal models of colitis, this compound decreases expression of IL-6, NF-κB, and TNF-α, resulting in decreases in weight loss, disease activity, and mortality. Sanguinarine increases oxidative stress and induces DNA damage in species of Microcystis, a cyanobacterium, inhibiting cell division. In species of Bacillus, this compound decreases bacterial membrane potential. Sanguinarine may also inhibit tubulin polymerization, allosterically activate AMPK, and inhibit amino acid carboxylase.

Product Info

Cas No.

5578-73-4

Purity

≥98%

Formula

C20H14ClNO4

Formula Wt.

367.78

Chemical Name

24-methyl-5,7,18,20-tetraoxa-24-azoniahexacyclo[11.11.0.02,10.04,8.014,22.017,21]tetracosa-1(24),2,4(8),9,11,13,15,17(21),22-nonaene;chloride

IUPAC Name

13-Methyl[1,3]benzodioxolo[5,6-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium chloride

Synonym

Viadent

Solubility

Soluble in methanol, water (slightly), DMSO (10 mM), and ethanol (5 mM).

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

S0254 MSDS PDF

Info Sheet

S0254 Info Sheet PDF

References

Park SY, Jin ML, Kim YH, et al. Sanguinarine inhibits invasiveness and the MMP 9 and COX 2 expression in TPA-induced breast cancer cells by inducing HO-1 expression. Oncol Rep. 2014 Jan;31(1):497-504. PMID: 24220687.

Shao J, Liu D, Gong D, et al. Inhibitory effects of sanguinarine against the cyanobacterium Microcystis aeruginosa NIES-843 and possible mechanisms of action. Aquat Toxicol. 2013 Oct 15;142-143:257-63. PMID: 24060579.

Dong XZ, Zhang M, Wang K, et al. Sanguinarine inhibits vascular endothelial growth factor release by generation of reactive oxygen species in MCF-7 human mammary adenocarcinoma cells. Biomed Res Int. 2013;2013:517698. PMID: 23762849.

Niu X, Fan T, Li W, et al. Protective effect of sanguinarine against acetic acid-induced ulcerative colitis in mice. Toxicol Appl Pharmacol. 2013 Mar 15;267(3):256-65. PMID: 23352506.

Foss MH, Eun YJ, Grove CI, et al. Inhibitors of bacterial tubulin target bacterial membranes in vivo. Medchemcomm. 2013 Jan 1;4(1):112-119. PMID: 23539337.

Choi J, He N, Sung MK, et al. Sanguinarine is an allosteric activator of AMP-activated protein kinase. Biochem Biophys Res Commun. 2011 Sep 23;413(2):259-63. PMID: 21884681.

Drsata J, Ulrichová J, Walterová D. Sanguinarine and chelerythrine as inhibitors of aromatic amino acid decarboxylase. J Enzyme Inhib. 1996;10(4):231-237. PMID: 8872743.

Wolff J, Knipling L. Antimicrotubule properties of benzophenanthridine alkaloids. Biochemistry. 1993 Dec 7;32(48):13334-9. PMID: 7902132.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C211324

    CFI-400945

    PLK4 inhibitor.

    ≥98%
  • C5592

    CNX-774

    BTK inhibitor.

    ≥98%
  • B6800

    Bradykinin Triacetate

    Natriuretic, vasodilatory peptide; B1/2 agonist...

    ≥95%
  • N3210

    Nicergoline

    Ergot derivative found in Claviceps; α1-adrene...

    ≥98%
  • O783743

    OTSSP167 Hydrochloride

    MELK inhibitor.

    ≥98%
  • G7444

    GSK-1070916

    AurKB/C inhibitor.

    ≥98%
  • L1982

    Leupeptin Hemisulfate

    Protease inhibitor.

    ≥95%
  • V9201

    VX-11e

    ERK2 inhibitor, potential AurKA, GSK3, CDK2, FL...

    ≥98%
  • M0248

    Manidipine Dihydrochloride

    Dihydropyridine; L-type and T-type Ca2+ channel...

    ≥99%
  • S0930

    Schisantherin A

    Dibenzocyclooctadiene found in Schisandra.

    ≥98%
  • T698579

    Tropodithietic Acid

    Produced by various marine proteobacteria

    ≥99%
  • N1982

    Neuromedin U, rat

    Endogenous neuropeptide, involved in energy hom...

    ≥95%
  • O4102

    Okadaic Acid Ammonium

    Shellfish toxin produced by dinoflagellates and...

    ≥98%
  • V0269

    Vardenafil Dihydrochloride

    PDE5 inhibitor.

    ≥99%
  • H1894

    Hexestrol

    Synthetic catechol; ER agonist, microtubule pol...

    ≥98%
  • T5605

    Tobramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • S8045

    S-Sulforaphane

    Synthetic antioxidant that induces phase II enz...

    ≥96%
  • A7309

    Ascorbyl Palmitate

    Fat-soluble vitamin C derivative.

    ≥95%
  • T0103

    Taxol Side Chain Diol

    Side chain attached to various taxanes.

    ≥98%
  • B0397

    BAY80-6946 Hydrochloride

    pan-PI3K inhibitor

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only