LKT Labs

Biochemicals for Life Science Research

Sermorelin Acetate

Sermorelin Acetate

Product ID S1969
Cas No. 86168-78-7
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $254.70 Please Inquire
5 mg $851.80 Please Inquire
10 mg $1,413.20 Please Inquire
Bulk Quote

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Description

Sermorelin is a synthetic 28-amino acid peptide analog of growth hormone-releasing hormone (GHRH). Sermorelin exhibits immunomodulatory and pro-angiogenic activities. In vivo, sermorelin stimulates secretion of growth hormone from the pituitary gland; it also increases IGF-1 secretion and increases the number of activated immune cells in circulation. Sermorelin induces histamine release from mast cells in a Ca2+-dependent manner. Additionally, this peptide increases secretion of VEGF and chromogranin A, increasing proliferation in neuroendocrine tumor cells.

Product Info

Cas No.

86168-78-7
Purity

≥95%
Formula

C149H246N44O42S
Formula Wt.

3357.88
Synonym

GHRH(1-29)NH2, human
Solubility

Soluble in formic acid (1 mg/mL), DMSO.

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

S1969 MSDS PDF
Info Sheet

S1969 Info Sheet PDF

References

Stepień T, Sacewicz M, Lawnicka H, et al. Stimulatory effect of growth hormone-releasing hormone (GHRH(1-29)NH2) on the proliferation, VEGF and chromogranin A secretion by human neuroendocrine tumor cell line NCI-H727 in vitro. Neuropeptides. 2009 Oct;43(5):397-400. PMID: 19747727.

Khorram O, Yeung M, Vu L, et al. Effects of [norleucine27]growth hormone-releasing hormone (GHRH) (1-29)-NH2 administration on the immune system of aging men and women. J Clin Endocrinol Metab. 1997 Nov;82(11):3590-6. PMID: 9360512.

Estévez MD, Alfonso A, Vieytes MR, et al. Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release. Inflamm Res. 1995 Feb;44(2):87-91. PMID: 7544679.

Sato M, Chihara K, Kita T, et al. Physiological role of somatostatin-mediated autofeedback regulation for growth hormone: importance of growth hormone in triggering somatostatin release during a trough period of pulsatile growth hormone release in conscious male rats. Neuroendocrinology. 1989 Aug;50(2):139-51. PMID: 2571099.

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