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Speract

Speract

Product ID S6019
Cas No. 76901-59-2
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $130.80 In stock
2 mg $220.70 In stock
5 mg $392.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Speract is a decapeptide derived from the outer envelope of the egg; it stimulates motility in spermatozoa. Speract activates its own receptor, a receptor in the scavenger receptor family. Speract increases flagellar Ca2+ levels and increases intracellular Na+, cAMP, and cGMP. Speract also activates K+ channels and alters membrane potential.

Product Info

Cas No.

76901-59-2

Purity

≥95%

Formula

C38H57N11O14

Formula Wt.

891.94

IUPAC Name

3-[[2-[(2-aminoacetyl)amino]-3-phenylpropanoyl]amino]-4-[[1-[[4-amino-1-[[2-[[2-[[2-[[1-(carboxymethylamino)-3-methyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-2-oxoethyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid

Synonym

Sperm-activating Peptide H-1

Solubility

Soluble in DMSO.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S6019 MSDS PDF

Info Sheet

S6019 Info Sheet PDF

References

Guerrero A, Nishigaki T, Carneiro J, et al. Tuning sperm chemotaxis by calcium burst timing. Dev Biol. 2010 Aug 1;344(1):52-65. PMID: 20435032.

Darszon A, Treviño CL, Wood C, et al. Ion channels in sperm motility and capacitation. Soc Reprod Fertil Suppl. 2007;65:229-44. PMID: 17644965.

Wood CD, Nishigaki T, Tatsu Y, et al. Altering the speract-induced ion permeability changes that generate flagellar Ca2+ spikes regulates their kinetics and sea urchin sperm motility. Dev Biol. 2007 Jun 15;306(2):525-37. PMID: 17467684.

Rodríguez E, Darszon A. Intracellular sodium changes during the speract response and the acrosome reaction in sea urchin sperm. J Physiol. 2003 Jan 1;546(Pt 1):89-100. PMID: 12509481.

Cardullo RA, Herrick SB, Peterson MJ, et al. Speract receptors are localized on sea urchin sperm flagella using a fluorescent peptide analog. Dev Biol. 1994 Apr;162(2):600-7. PMID: 8150218.

Babcock DF, Bosma MM, Battaglia DE, et al. Early persistent activation of sperm K+ channels by the egg peptide speract. Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):6001-5. PMID: 1631086.

Custom Order

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