• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Spinorphin, bovine

Spinorphin, bovine

Product ID S6134
Cas No. 137201-62-8
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $233.20 Please Inquire
10 mg $388.40 In stock
25 mg $776.80 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Spinorphin is a heptapeptide with the sequence L-V-V-Y-P-W-T. Spinorphin is an endogenous enkephalinase inhibitor, antagonizing enzymes such as aminopeptidase IV, neutral endopeptidase, dipeptidyl peptidase III (DPP3), and angiotensin-converting enzyme (ACE); it also acts as an antagonist at the P2X3 receptor. Spinorphin exhibits antinociceptive, antidepressant, gastrointestinal motility modulating, anti-inflammatory, and immunomodulatory activities. Spinorphin also acts as an antagonist at N-formylpeptide receptors, preventing binding of chemotactic f-MLF to its receptor on polymorphonuclear (PMN) neutrophils and inhibiting neutrophil functionality.

Product Info

Cas No.

137201-62-8

Purity

≥95%

Formula

C45H64N8O10

Formula Wt.

877.06

IUPAC Name

(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoic acid

Solubility

Soluble in water (1 mg/mL).

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

S6134 MSDS PDF

Info Sheet

S6134 Info Sheet PDF

References

Thanawala V, Kadam VJ, Ghosh R. Enkephalinase inhibitors: potential agents for the management of pain. Curr Drug Targets. 2008 Oct;9(10):887-94. PMID: 18855623.

Jung KY, Moon HD, Lee GE, et al. Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. PMID: 17676725.

Yamamoto Y, Ono H, Ueda A, et al. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation. Curr Protein Pept Sci. 2002 Dec;3(6):587-99. PMID: 12470213.

Liang TS, Gao JL, Fatemi O, et al. The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J Immunol. 2001 Dec 1;167(11):6609-14. PMID: 11714831.

Nishimura K, Hazato T. Isolation and identification of an endogenous inhibitor of enkephalin-degrading enzymes from bovine spinal cord. Biochem Biophys Res Commun. 1993 Jul 30;194(2):713-9. PMID: 8343155.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T0298

    Tazobactam

    β-lactamase inhibitor.

    ≥98%
  • J974440

    JZL184

    MAGL inhibitor.

    ≥98%
  • O4578

    Oltipraz

    Antioxidant; Nrf2 activator.

    ≥98%
  • T5611

    δ-Tocotrienol

    Antioxidant, vitamin E derivative found in vege...

    ≥98%
  • L5750

    Lomeguatrib

    MGMT inhibitor.

    ≥98%
  • O5212

    Ondansetron Hydrochloride Dihydrate

    5-HT3 antagonist.

    ≥98%
  • F8250

    Fumitremorgin C

    Mycotoxin found in Aspergillus and Penicillum; ...

    ≥98%
  • P3465

    Piperine

    Alkaloid found in black and long peppers; TRPV1...

    ≥95%
  • N5550

    Nomilin

    Triterpene found in species of Citrus; HIV-1 pr...

    ≥98%
  • E7858

    Etoricoxib

    NSAID; COX-2 inhibitor.

    ≥99%
  • Q8019

    Quetiapine Fumarate

    5-HT1A and σ1/2 agonist, 5-HT2A/2C/6/7, D1-4, ...

    ≥99%
  • N5766

    L-(-)-Norepinephrine Bitartrate Monohydrate

    Endogenous hormone and neurotransmitter involve...

    ≥98%
  • C0800

    C59

    PORCN inhibitor.

    ≥98%
  • N6272

    NPS-2143 Hydrochloride

    Ca2+-sensing receptor antagonist.

    ≥99%
  • B564086

    Boceprevir

    Inhibits HCV replication

    ≥98%
  • I7746

    1-Isothiocyanato-7-(methylsulfenyl)-heptane

    ITC, erucin analog.

    ≥98%
  • C4758

    Closantel Sodium

    Protonophore; chitinase OvCHT1 inhibitor.

    ≥98%
  • A7462

    Aspartame

    Dipeptide ester, commercial sweetener.

    ≥98%
  • A5072

    Amsacrine

    Acridine derivative, DNA intercalator; topoisom...

    ≥98%
  • I5313

    Indinavir Sulfate

    HIV protease, GLUT4, calpain inhibitor.

    ≥99%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only