Description
SR-717 Lithium salt is a STING agonist.
SR-717 Lithium Salt
Product ID S680017
Cas No. 2375421-09-1
Purity ≥98%
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Product Info
| Cas No. | 2375421-09-1 |
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| Purity | ≥98% |
| Formula | C15H8F2LiN5O3 |
| Formula Wt. | 351.20 |
| IUPAC Name | lithium;4,5-difluoro-2-[(6-imidazol-1-ylpyridazine-3-carbonyl)amino]benzoate |
| Synonym | SR717 Lithium |
| Appearance | Grayish-white solid |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| Info Sheet |
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References
Fang D, Duan W, Zhai X, et al. SR-717, a non-nucleotide STING agonist, displayed anti-radiation activity in a IL-6 dependent manner. FASEB J. 2025 Jun 15;39(11):e70644. PMID: 40448435
Huang R, Shi Q, Zhang S, et al. Inhibition of the cGAS-STING pathway attenuates lung ischemia/reperfusion injury via regulating endoplasmic reticulum stress in alveolar epithelial type II cells of rats. J Inflamm Res. 2022 Sep 5;15:5103-5119. PMID: 36091334
Wang L, Zhang Y, Ren Y, et al. Pharmacological targeting if cGAS/STING-YAP axis suppresses pathological angiogenesis and ameliorates organ fibrosis. Eur J Pharmacol. 2022 Oct 15;932:175241
Chin E, Yu C, Vartabedian V, et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science. 2020 Aug 21;369(6506):993-999. PMID: 32820126