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Strontium Ranelate

Strontium Ranelate

Product ID S7970
Cas No. 135459-87-9
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $61.40 In stock
1 g $125.80 In stock
5 g $275.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Strontium ranelate (SR) prevents deterioration of bone tissue microarchitecture in osteoporosis. When used clinically to prevent osteoporosis, SR stimulates pre-osteoblast replication and decreases osteoclast activity, increasing the ultimate load of intact bones, making them stiffer, harder, and tougher. In vitro, SR inhibited activation of NF-κB, promoting osteoblast differentiation and suppressing osteoclast formation. In other cellular models, SR stimulates phosphorylation of ERK and increases expression of osteocalcin and bone morphogenetic protein 2 (BMP2), potentially through activation of calcium-sensing receptor CaR.

Product Info

Cas No.

135459-87-9

Purity

≥98%

Formula

C12H6N2O8S • Sr2

Formula Wt.

513.49

Chemical Name

distrontium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4-cyanothiophene-2-carboxylate

IUPAC Name

distrontium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4- cyanothiophene-2-carboxylate

Synonym

Protelos, distrontium renelate, Protos

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

S7970 MSDS PDF

Info Sheet

S7970 Info Sheet PDF

References

Cattani-Lorente M, Rizzoli R, Ammann P. In vitro bone exposure to strontium improves bone material level properties. Acta Biomater. 2013 Jun;9(6):7005-13. PMID: 23454213.

Rodríguez J, Escudero ND, Mandalunis PM. Effect of strontium ranelate on bone remodeling. Acta Odontol Latinoam. 2012;25(2):208-13. PMID: 23230643.

Yamaguchi M, Weitzmann MN. The intact strontium ranelate complex stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation. Mol Cell Biochem. 2012 Jan;359(1-2):399-407. PMID: 21874315.

Takaoka S, Yamaguchi T, Yano S, et al. The Calcium-sensing Receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization. Horm Metab Res. 2010 Aug;42(9):627-31. PMID: 20560105.

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