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T2 toxin triol is a Fusarium trichothecene mycotoxin. In vitro, this compound displays significant cytotoxic activity, inducing breakdown of polyribosomes and inhibiting polypeptide chain elongation in eukaryotes. Additionally, T2 triol exhibits cytotoxicity in Jurkat T cells. This mycotoxin was initially produced by mycoplasma in barley, maize, oats, and other livestock feed grains.
| Cas No. | 34114-98-2 |
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| Purity | ≥97%, TLC |
| Formula | C20H30O7 |
| Formula Wt. | 382.45 |
| Chemical Name | 12,13-Epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol 8-isovalerate 3-alpha,4-beta,15-Trihydroxy-8-alpha-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene |
| IUPAC Name | [(1S,2R,4S,7R,9R,10R,11S,12S)-10,11-dihydroxy-2-(hydroxymethyl)-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-4-yl] 3-methylbutanoate |
| Synonym | T2 triol, T-2 Triol |
| Melting Point | 162°C |
| Solubility | DMSO, Dichloromethane, methanol. Slightly soluble in water. |
| Appearance | White to off white powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Alassane-Kpembi I, Kolf-Clauw M, Gauthier T, et al. New insights into mycotoxin mixtures: the toxicity of low doses of Type B trichothecenes on intestinal epithelial cells is synergistic. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):191-8. PMID: 23735874.
Tan DC, Flematti GR, Ghisalberti EL, et al. Mycotoxins produced by Fusarium species associated with annual legume pastures and 'sheep feed refusal disorders' in Western Australia. Mycotoxin Res. 2011 May;27(2):123-35. PMID: 23605703.
Edwards SG. Fusarium mycotoxin content of UK organic and conventional oats. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2009 Jul;26(7):1063-9. PMID: 19680981.