LKT Labs

Biochemicals for Life Science Research

Tanshinone IIA

Product ID T0154
Cas No. 568-72-9
Purity ≥93%
Product Unit SizeCostQuantityStock
10 mg $118.90 In stock
25 mg $246.60 In stock
100 mg $500.10 In stock
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Description

Tanshinone IIA is found in Salvia and exhibits anticoagulant, neuroprotective, cognition enhancing, anti-atherosclerotic, and anticancer chemotherapeutic activities. Tanshinone IIA inhibits platelet aggregation, increasing bleeding time in vivo. Tanshinone IIA also decreases TNF-α-induced expression of VCAM-1 and ICAM-1 in vitro. In animal models of Alzheimer’s disease, tanshinone IIA decreases learning and memory deficits and suppresses expression of iNOS and matric metalloproteinase 2 (MMP2). In glioblastoma cells, this compound induces apoptosis and downregulates expression of STAT3 and IL-6; it also inhibits breast cancer tumor growth in animal models. Tanshinone IIA inhibits monoacylglycerol lipase (MAGL).

Product Info

Cas No.

568-72-9
Purity

≥93%
Formula

C19H18O3

Formula Wt.

294.34
Chemical Name

Phenanthro(1,2-b)furan-10,11-dione, 6,7,8,9-tetrahydro- 1,6,6-trimethyl-

IUPAC Name

1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione
Synonym

Dan Shen Ketone, Tanshinone II, Tanshinone B
Melting Point

198-200°C
Solubility

Soluble in DMSO.
Appearance

Red crystal

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

T0154 MSDS PDF
Info Sheet

T0154 Info Sheet PDF

References

Maione F, De Feo V, Caiazzo E, et al. Tanshinone IIA, a major component of Salvia milthorriza Bunge, inhibits platelet activation via Erk-2 signaling pathway. J Ethnopharmacol. 2014 Sep 11;155(2):1236-42. PMID: 25038434.

Yang L, Guo H, Dong L, et al. Tanshinone IIA inhibits the growth, attenuates the stemness and induces the apoptosis of human glioma stem cells. Oncol Rep. 2014 Sep;32(3):1303-11. PMID: 24970314.

Jiang P, Li C, Xiang Z, et al. Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP 2 and NF κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease. Mol Med Rep. 2014 Aug;10(2):689-94. PMID: 24859152.

Chang CC, Chu CF, Wang CN, et al. The anti-atherosclerotic effect of tanshinone IIA is associated with the inhibition of TNF-α-induced VCAM-1, ICAM-1 and CX3CL1 expression. Phytomedicine. 2014 Feb 15;21(3):207-16. PMID: 24157079.

Lin C, Wang L, Wang H, et al. Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL-6/STAT3/NF-kB signaling pathways. J Cell Biochem. 2013 Sep;114(9):2061-70. PMID: 23553622.

Li W, Li J, Ashok M, et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attentuating a late-acting proinflammatory mediator, high mobility group box 1. J Immunol. 2007 Mar 15;178(6):3856-3864. PMID: 17339485.

Zhang Y, Won SH, Jiang C, et al. Tanshinones fmor Chinese medicinal herb Danshen (Salvia miltiorrhiza Bunge) suppress prostate cancer growth and androgen receptor signaling. Pharm Res. 2012 Jun;29(6):1595-1608. PMID: 22281759.

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