LKT Labs

Biochemicals for Life Science Research

Ticagrelor

Product ID T3200
Cas No. 274693-27-5
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $48.60 In stock
25 mg $81.00 In stock
100 mg $189.00 In stock
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Description

Ticagrelor is a clinically approved reversible platelet aggregation inhibitor that exhibits anticoagulant and antithrombotic activities. Ticagrelor is primarily used to increase coronary blood flow velocity and to prevent stroke, heart attack, and myocardial infarction. This compound has a rapid onset and offset of action and has been shown to act as a nucleoside analog with an overall similarity to adenosine; it is an allosteric antagonist for the P2Y12 ADP receptor, inhibiting downstream fibrinogen cross-linking between platelets.

Product Info

Cas No.

274693-27-5

Purity

≥98%
Formula

C23H28F2N6O4S
Formula Wt.

522.57
Chemical Name

(1S,2S,3R,5S)-3-[7-[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino]-5-(propylthio)- 3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
IUPAC Name

(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3, 4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4, 5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
Synonym

AZD-6140
Solubility

DMSO 100 mg/mL (191.36 mM) Ethanol 53 mg/mL (101.42 mM) Water Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

T3200 MSDS PDF
Info Sheet

T3200 Info Sheet PDF

References

Rahman M, Gustafsson D, Wang Y, et al. Ticagrelor reduces neutrophil recruitment and lung damage in abdominal sepsis. Platelets. 2013 Jul 15. [Epub ahead of print] PMID: 23855479.

Wittfeldt A, Emanuelsson H, Brandrup-Wognsen G, et al. Ticagrelor enhances adenosine-induced coronary vasodilatory responses in humans. J Am Coll Cardiol. 2013 Feb 19;61(7):723-7. PMID: 23312702.

Birkeland K, Parra D, Rosenstein R. Antiplatelet therapy in acute coronary syndromes: focus on ticagrelor. J Blood Med. 2010;1:197-219. PMID: 22282698.

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