TL-32711

Name: TL-32711
SKU: T4400
Availability: InStock

Product ID T4400

Cas No. 1260251-31-7

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

TL-32711 is a Smac mimetic that is currently in clinical trials as a potential treatment for a variety of cancers. TL-32711 inhibits members of the inhibitor of apoptosis protein (IAP) family proteins, inducing degradation of cIAP1 and cIAP2. TL-32711 exhibits anticancer chemotherapeutic activity, inhibiting NF-κB activation and tumor growth in animal models. In acute myelogenous leukemia (AML) cells, this compound induces caspase 8-mediated apoptosis. This compound also improves the efficacy of co-administered antivirals in models of hepatitis B infection.

Product Info

Cas No.	1260251-31-7
Purity	≥98%
Formula	C₄₂H₅₆F₂N₈O₆
Formula Wt.	806.94
IUPAC Name	(2S)-N-[(2S)-1-[(2R,4S)-2-[[6-fluoro-2-[6-fluoro-3-[[(2R,4S)-4-hydroxy-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidin-2-yl]methyl]-1H-indol-2-yl]-1H-indol-3-yl]methyl]-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl]-2-(methylamino)propanamide
Synonym	Birinapant
Solubility	DMSO 100 mg/mL (123.92 mM) Ethanol 55 mg/mL (68.15 mM) Water Insoluble
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	T4400 MSDS PDF
Info Sheet	T4400 Info Sheet PDF

References

Ebert G, Allison C, Preston S, et al. Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5803-8. PMID: 25902530.

Benetatos CA, Mitsuuchi Y, Burns JM, et al. Birinapant(TL32711), a Bivalent Smac Mimetic, Targets TRAF2-associated cIAPs, Abrogates TNF-induced NF-κB Activation and is Active in Patient-Derived Xenograft Models. Mol Cancer Ther. 2014 Feb 21. [Epub ahead of print]. PMID: 24563541.

Carter BZ, Mak PY, Mak DH, et al. Synergistic Targeting of AML Stem/Progenitor Cells With IAP Antagonist Birinapant and Demethylating Agents. J Natl Cancer Inst. 2014 Feb 1;106(2):djt440. PMID: 24526787.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

TL-32711

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Paxilline

Lorlatinib

Pituitary Adenylate Cyclase-activating Peptide (6-38), human/sheep/rat

Alsterpaullone

Daunorubicin Hydrochloride

Oxaliplatin

Lopinavir

Indole-3-carbinol

Icariin

Fenbufen

Crotamiton

Dermorphin

L-Arginine Hydrochloride

KGDS

Rhynchophylline

16-O-Methylcafestol

3-Formylrifamycin

Berberine Chloride

Lapatinib Ditosylate Monohydrate

Enniatin A1

Footer