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Torin 1

Torin 1

Product ID T5870
Cas No. 1222998-36-8
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $99.80 In stock
10 mg $131.30 In stock
25 mg $288.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Torin 1 is a tricyclic benzonaphthyridinone that inhibits mTORC1/2 and exhibits anti-inflammatory, anti-angiogenic, anti-metastatic, and anticancer chemotherapeutic activities. In macrophages, torin 1 decreases cytokine production and inflammatory response signaling. In colorectal cancer cells, this compound induces apoptosis and inhibits growth, motility, invasiveness, and survival; it also inhibits tumor growth and vessel formation in vivo.

Product Info

Cas No.

1222998-36-8

Purity

≥98%

Formula

C35H28F3N5O2

Formula Wt.

607.64

Chemical Name

1-[4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-quinolin-3-ylbenzo[h][1,6]naphthyridin-2-one

IUPAC Name

1-[4-(4-Propionyl-1-piperazinyl)-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h][1,6]naphthyridin-2(1H)-one

Synonym

Torin-1

Solubility

1mM with gentle warming in DMSO

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T5870 MSDS PDF

Info Sheet

T5870 Info Sheet PDF

References

Shappley RK, Spentzas T. Differential Role of Rapamycin and Torin/KU63794 in Inflammatory Response of 264.7 RAW Macrophages Stimulated by CA-MRSA. Int J Inflam. 2014;2014:560790. PMID: 24800098.

Francipane MG, Lagasse E. Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1. Oncotarget. 2013 Nov;4(11):1948-62. PMID: 24185040.

Liu Q, Chang JW, Wang J, et al. Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J Med Chem. 2010 Oct 14;53(19):7146-55. PMID: 20860370.

Custom Order

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