Transactivator of Transcription Peptide

Name: Transactivator of Transcription Peptide
SKU: T0076
Availability: InStock

Product ID T0076

Cas No.

Purity ≥95%

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Description
Product Info
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References

Description

Transactivator of transcription (TAT) protein is produced by HIV-1 and is involved in the induction of HIV-associated neurologic disorders (HAND). TAT is a neurotoxin that infects neurons, which HIV itself is unable to do. In neurons, TAT increases the number of inhibitory synapses and decreases the number of excitatory synapses in a Ca2+-dependent manner. TAT also activates microglia and other myeloid cells, disrupting cytokine/chemokine homeostasis and inducing neuroinflammation. This peptide sequence (YGRKKRRQRRR) represents the protein transduction (cell-penetrating) domain of TAT.

Product Info

Purity	≥95%
Formula	C₆₄H₁₁₉N₃₃O₁₃
Formula Wt.	1558.88
Synonym	TAT, TAT peptide, HIV-1 TAT Protein Peptide, YGRKKRRQRRR
Solubility	Soluble in water.

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	T0076 MSDS PDF
Info Sheet	T0076 Info Sheet PDF

References

Hargus NJ, Thayer SA. Human immunodeficiency virus-1 Tat protein increases the number of inhibitory synapses between hippocampal neurons in culture. J Neurosci. 2013 Nov 6;33(45):17908-20. PMID: 24198379.

Bethel-Brown C, Yao H, Callen S, et al. HIV-1 Tat-mediated induction of platelet-derived growth factor in astrocytes: role of early growth response gene 1. J Immunol. 2011 Apr 1;186(7):4119-29. PMID: 21368226.

Lu SM, Tremblay MÈ, King IL, et al. HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PLoS One. 2011;6(9):e23915. PMID: 21912650.