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Trazodone Hydrochloride

Trazodone Hydrochloride

Product ID T7003
Cas No. 25332-39-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 g $71.50 In stock
5 g $204.30 In stock
25 g $714.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Trazodone hydrochloride exhibits antidepressant, anxiolytic, and hypnotic activity. Trazodone hydrochloride inhibits 5-HT2 receptors, α1/2-adrenergic receptors, histamine receptors, and serotonin transporters (SERT), and also acts as a partial agonist at 5-HT1A receptors. Although trazodone hydrochloride is clinically acceptable for treatment of anxiety, depression, and insomnia, it is also often used to treat erectile dysfunction due to its inhibition of adrenergic receptors. In addition to its modulation of neurotransmitters, this compound also weakly inhibits voltage-gated K+ channels, binding to closed channels and accelerating inactivation of open channels.

Product Info

Cas No.

25332-39-2

Purity

≥98%

Formula

C19H22ClN5O • HCl

Formula Wt.

408.33

IUPAC Name

2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one;hydrochloride

Melting Point

223-226°C

Solubility

Trazodone hydrochloride dissolves in methanol at 25 mg/ml to yield a clear, colorless solution. It also dissolves in water at 50 mg/ml, with heating to yield a hazy colorless solution. Furthermore, the product is soluble in DMSO or in 0.1 N HCl (7.4 mg/ml).

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T7003 MSDS PDF

Info Sheet

T7003 Info Sheet PDF

References

Chae YJ, Choi JS, Hahn SJ. Inhibition of Kv4.3 potassium channels by trazodone. Naunyn Schmiedebergs Arch Pharmacol. 2013 Aug;386(8):711-9. PMID: 23615873.

Odagaki Y, Toyoshima R, Yamauchi T. Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding. J Psychopharmacol. 2005 May;19(3):235-41. PMID: 15888508.

Otani K, Yasui N, Kaneko S, et al. Trazodone treatment increases plasma prolactin concentrations in depressed patients. Int Clin Psychopharmacol. 1995 Jun;10(2):115-7. PMID: 7673654.

Haria M, Fitton A, McTavish D. Trazodone. A review of its pharmacology, therapeutic use in depression and therapeutic potential in other disorders. Drugs Aging. 1994 Apr;4(4):331-55. PMID: 8019056.

Marek GJ, McDougle CJ, Price LH, et al. A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action. Psychopharmacology (Berl). 1992;109(1-2):2-11. PMID: 1365657.

Scharf MB, Sachais BA. Sleep laboratory evaluation of the effects and efficacy of trazodone in depressed insomniac patients. J Clin Psychiatry. 1990 Sep;51 Suppl:13-7. PMID: 2211559.

Custom Order

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