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Tropisetron Hydrochloride

Tropisetron Hydrochloride

Product ID T7156
Cas No. 105826-92-4
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $104.10 In stock
50 mg $295.50 In stock
100 mg $433.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tropisetron is an antagonist at 5-HT3 receptors and partial agonist at α7 nicotinic acetylcholine receptors (nAChRs) that exhibits antiemetic, analgesic, anti-inflammatory, nephroprotective, neuroprotective, and anti-fibrotic activities. In animal models of nephrotoxicity, tropisetron decreases levels of TNF-α, IL-1β, and iNOS and improves renal pathology. Additionally, tropisetron increases survival of glutamatergic neurons by decreasing levels of p38 MAPK and inducing NMDA receptor internalization in vitro. Tropisetron also inhibits collagen synthesis and fibrosis in animal models of scleroderma.

Product Info

Cas No.

105826-92-4

Purity

≥98%

Formula

C17H20N2O2 • HCl

Formula Wt.

320.82

Chemical Name

1H-Indole-3-carboxylic acid (3-endo)-8-methyl- 8-azabicyclo[3.2.1]oct-3-yl ester monohydrochloride

IUPAC Name

(8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 1H-indole-3-carboxylate;hydrochloride

Synonym

Navoban, Novaban

Melting Point

283-285°C (dec)

Solubility

Soluble in water.

Appearance

A White Crystalline Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

T7156 MSDS PDF

Info Sheet

T7156 Info Sheet PDF

References

Zirak MR, Rahimian R, Ghazi-Khansari M, et al. Tropisetron attenuates cisplatin-induced nephrotoxicity in mice. Eur J Pharmacol. 2014 Jun 4. [Epub ahead of print]. PMID: 24905858.

Swartz MM, Linn DM, Linn CL. Tropisetron as a neuroprotective agent against glutamate-induced excitotoxicity and mechanisms of action. Neuropharmacology. 2013 Oct;73:111-21. PMID: 23727438.

Stegemann A, Sindrilaru A, Eckes B, et al. Tropisetron suppresses collagen synthesis in skin fibroblasts via α7 nicotinic acetylcholine receptor and attenuates fibrosis in a scleroderma mouse model. Arthritis Rheum. 2013 Mar;65(3):792-804. PMID: 23440693.

Bandschapp O, Filitz J, Urwyler A, et al. Tropisetron blocks analgesic action of acetaminophen: a human pain model study. Pain. 2011 Jun;152(6):1304-10. PMID: 21420788.

Hsu ES. A review of granisetron, 5-hydroxytryptamine3 receptor antagonists, and other antiemetics. Am J Ther. 2010 Sep-Oct;17(5):476-86. PMID: 20844345.

Custom Order

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