Tubastatin A Hydrochloride

Name: Tubastatin A Hydrochloride
SKU: T8006
Availability: InStock

Product ID T8006

Cas No. 1310693-92-5

Purity ≥98%

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Description

Tubastatin A is an inhibitor of class IIb histone deacetylases (HDACs), such as HDAC6 and HDAC10. Tubastatin A exhibits cardioprotective and anticancer chemotherapeutic activities. In vivo, tubastatin A decreases levels of α-tubulin and protects against atrial fibrillation-related atrial remodeling. Additionally, tubastatin A restores expression of primary cilia and decreases cell proliferation and growth in cholangiocarcinoma cells; in similar animal models, this compound inhibits tumor growth.

Product Info

Cas No.	1310693-92-5
Purity	≥98%
Formula	C₂₀H₂₁N₃O₂ • HCl
Formula Wt.	371.86
IUPAC Name	N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;hydrochloride
Synonym	Tubastatin A HCl
Solubility	DMSO 67 mg/mL (199.76 mM) Water Insoluble Ethanol Insoluble
Appearance	White to off white powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	T8006 MSDS PDF
Info Sheet	T8006 Info Sheet PDF

References

Zhang D, Wu CT, Qi X, et al. Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation. Circulation. 2014 Jan 21;129(3):346-58. PMID: 24146251.

Gradilone SA, Radtke BN, Bogert PS, et al. HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res. 2013 Apr 1;73(7):2259-70. PMID: 23370327.

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Tubastatin A Hydrochloride

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

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