LKT Labs

Biochemicals for Life Science Research

Tubastatin A Hydrochloride

Tubastatin A Hydrochloride

Product ID T8006
Cas No. 1310693-92-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.70 In stock
5 mg $150.40 In stock
10 mg $277.90 In stock
Bulk Quote

Quicklinks

Description

Tubastatin A is an inhibitor of class IIb histone deacetylases (HDACs), such as HDAC6 and HDAC10. Tubastatin A exhibits cardioprotective and anticancer chemotherapeutic activities. In vivo, tubastatin A decreases levels of α-tubulin and protects against atrial fibrillation-related atrial remodeling. Additionally, tubastatin A restores expression of primary cilia and decreases cell proliferation and growth in cholangiocarcinoma cells; in similar animal models, this compound inhibits tumor growth.

Product Info

Cas No.

1310693-92-5
Purity

≥98%
Formula

C20H21N3O2 • HCl
Formula Wt.

371.86
IUPAC Name

N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;hydrochloride
Synonym

Tubastatin A HCl
Solubility

DMSO 67 mg/mL (199.76 mM) Water Insoluble Ethanol Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T8006 MSDS PDF
Info Sheet

T8006 Info Sheet PDF

References

Zhang D, Wu CT, Qi X, et al. Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation. Circulation. 2014 Jan 21;129(3):346-58. PMID: 24146251.

Gradilone SA, Radtke BN, Bogert PS, et al. HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res. 2013 Apr 1;73(7):2259-70. PMID: 23370327.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S6018

    Spectinomycin Dihydrochloride Pentahydrate

    Aminocyclitol; protein synthesis inhibitor.

    ≥603 µg/mg (potency)
  • L5873

    Losartan Potassium

    AT1 antagonist.

    ≥98%
  • A4679

    Altrenogest

    Synthetic progestogen; PR agonist.

    ≥98%
  • A4850

    [His18]-Amylin, rat

    Endogenous peptide hormone inolved in gastric e...

    ≥95%
  • R2712

    Recombinant HCV-NS3 Antigens

    Recombinant HCV antigen fragment.

    ≥95%
  • G4481

    Glucagon-like Peptide I Amide (7-36), human

    Endogenous peptide hormone, GLP-1 fragment, inv...

    ≥95%
  • R5974

    Rosuvastatin Calcium

    Statin; HMG-CoA reductase inhibitor, potential ...

    ≥98%
  • A5035

    5-Aminosalicylic Acid

    Salicylic acid derivative; PPARγ agonist, pote...

    ≥98%
  • N5655

    Nonoxynol-9

    Nonoxynol surfactant.

    90-110%
  • L0209

    Lactoferrin, cow

    Endogenous glycoprotein; lactoferrin agonist.

    ≥92%
  • B7058

    Brompheniramine Maleate

    Pheniramine derivative; histamine H1 and mAChR ...

    ≥98%
  • P2919

    L-Phenylalaninol

    Non-essential amino acid alcohol.

    ≥98%
  • L1982

    Leupeptin Hemisulfate

    Protease inhibitor.

    ≥95%
  • E7578

    Estramustine

    Nitrogen mustard and estradiol derivative; micr...

    ≥97%
  • I7256

    Isobavachalcone

    Prenylated chalcone flavonoid found in Psoralea...

    ≥97%
  • I7556

    1-Isothiocyanato-7-(methylsulfonyl)-heptane

    ITC, erysolin analog.

    ≥98%
  • P7218

    Pseudoprotodioscin

    Steroidal saponin found in Tribulus, Trigonella...

    ≥98%
  • O486179

    Omeprazole Impurity C

    Impurity of omeprazole

    ≥99%
  • S0168

    Saracatinib

    Src and Abl inhibitor.

    ≥98%
  • M174446

    Meleagrin

    FabI inhibitor

    ≥99%