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Tubastatin A Hydrochloride

Tubastatin A Hydrochloride

Product ID T8006
Cas No. 1310693-92-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $97.70 In stock
5 mg $150.40 In stock
10 mg $277.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tubastatin A is an inhibitor of class IIb histone deacetylases (HDACs), such as HDAC6 and HDAC10. Tubastatin A exhibits cardioprotective and anticancer chemotherapeutic activities. In vivo, tubastatin A decreases levels of α-tubulin and protects against atrial fibrillation-related atrial remodeling. Additionally, tubastatin A restores expression of primary cilia and decreases cell proliferation and growth in cholangiocarcinoma cells; in similar animal models, this compound inhibits tumor growth.

Product Info

Cas No.

1310693-92-5

Purity

≥98%

Formula

C20H21N3O2 • HCl

Formula Wt.

371.86

IUPAC Name

N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide;hydrochloride

Synonym

Tubastatin A HCl

Solubility

DMSO 67 mg/mL (199.76 mM) Water Insoluble Ethanol Insoluble

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T8006 MSDS PDF

Info Sheet

T8006 Info Sheet PDF

References

Zhang D, Wu CT, Qi X, et al. Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation. Circulation. 2014 Jan 21;129(3):346-58. PMID: 24146251.

Gradilone SA, Radtke BN, Bogert PS, et al. HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res. 2013 Apr 1;73(7):2259-70. PMID: 23370327.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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