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Tubeimoside I

Tubeimoside I

Product ID T8004
Cas No. 102040-03-9
Purity ≥96%
Product Unit SizeCostQuantityStock
10 mg $114.70 In stock
25 mg $229.30 In stock
100 mg $744.90 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tubeimoside I is a triterpene saponin originally found in Bolbostemma that exhibits anti-inflammatory, antiviral, anticancer chemotherapeutic, and chemopreventive activities. Tubeimoside I inhibits LPS-stimulated production of TNF-α, IL-1β, and IL-6, preventing the development of pulmonary edema and infiltration of inflammatory cells in vivo. Tubeimoside I also induces G2/M phase cell cycle arrest and mitochondria-dependent apoptosis in esophageal squamous cell carcinoma cells, inhibiting cell proliferation; in other, similar cellular and animal models, this compound inhibits cell and tumor growth. Tubeimoside I binds tubulin at the colchicine site, inhibiting microtubule polymerization. Additionally, this compound inhibits production of HIV core protein p24 and infectivity of HIV-1 in vitro.

Product Info

Cas No.

102040-03-9

Purity

≥96%

Formula

C63H98O29

Formula Wt.

1319.43

Synonym

Tubeimoside 1

Melting Point

250-252°C

Appearance

White Crystalline Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T8004 MSDS PDF

Info Sheet

T8004 Info Sheet PDF

References

Wu Q, Sun G, Yuan X, et al. Tubeimoside-1 attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models. Immunopharmacol Immunotoxicol. 2013 Aug;35(4):514-23. PMID: 23844578.

Xu Y, Wang G, Chen Q, et al. Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death. Chin J Cancer Res. 2013 Jun;25(3):312-21. PMID: 23825908.

Ma R, Song G, You W, et al. Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin. Cancer Chemother Pharmacol. 2008 Sep;62(4):559-68. PMID: 18030471.

Yu L, Ma R, Wang Y, et al. Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum. Planta Med. 1994 Jun;60(3):204-8. PMID: 8073083.

Yu LJ, Ma RD, Jiang SB. Effects of tubeimoside-1 on HIV core protein p24 and cytopathogenesis in vitro. Zhongguo Yao Li Xue Bao. 1994 Mar;15(2):103-6. PMID: 8010099.

Yu LJ, Ma RD, Wang YQ, et al. Potent anti-tumorigenic effect of tubeimoside 1 isolated from the bulb of Bolbostemma paniculatum (Maxim) Franquet. Int J Cancer. 1992 Feb 20;50(4):635-8. PMID: 1537629.

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