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Tylosin Phosphate

Tylosin Phosphate

Product ID T9946
Cas No. 1405-53-4
Purity ≥90%
Product Unit SizeCostQuantityStock
1 g $48.60 In stock
5 g $139.00 In stock
10 g $243.20 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tylosin is a macrolide antibiotic originally produced by Streptomyces. Like other macrolides, tylosin binds the 50S subunit of the bacterial ribosome, suppressing mitochondrial protein translation; it inhibits peptidyl transferase, preventing translocation. Tylosin displays antibacterial efficacy against most gram positive and some gram negative bacteria such as Campylobacter.

Product Info

Cas No.

1405-53-4

Purity

≥90%

Formula

C46H77NO17 • H3PO4

Formula Wt.

1014.11

IUPAC Name

2-[(4R,5S,6S,7R,9R,11E,13E,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S, 6S)-4,5-dihydroxy-4, 6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl] oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3, 4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2, 10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde;phosphoric acid

Synonym

Farmazin TB, Tylosin phophate salt

Solubility

Soluble in water, alcohol or chloroform.

Appearance

White to almost white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T9946 MSDS PDF

Info Sheet

T9946 Info Sheet PDF

References

Liu M, Douthwaite S. Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. PMID: 12417742.

Zalacain M, Cundliffe E. Methylation of 23S rRNA caused by tlrA (ermSF), a tylosin resistance determinant from Streptomyces fradiae. J Bacteriol. 1989 Aug;171(8):4254-60. PMID: 2753855.

Custom Order

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