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[Tyr4]-Bombesin

Product ID B5649
Cas No.
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $74.10 Please Inquire
2 mg $126.00 Please Inquire
5 mg $222.50 Please Inquire
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  • Description
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Description

Bombesin is a gastrin-releasing peptide analog that binds bombesin and GRP receptors. Derivatives of bombesin are currently under investigation as cancer imaging tools, as bombesin receptors are often overexpressed in tumor tissues. Bombesin itself exhibits neuromodulatory, hepatoprotective, cardiomodulatory, and vasoconstrictive activities. Bombesin increases the frequency and amplitude of IPSCs in the entorhinal cortex, likely due to Ca2+-mediated increases in GABA release. In animal models of liver disease, bombesin increases proliferation of oval cells and hepatocytes, increases levels of glutathione, and decreases portal endotoxemia. Bombesin also exhibits pressor-like effects, increasing mean arterial pressure, blood pressure, and heart rate.

Product Info

Purity

≥95%

Formula

C74H109N24O19S

Formula Wt.

1670.90

Solubility

Soluble in water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B5649 MSDS PDF

Info Sheet

B5649 Info Sheet PDF

References

Zhang HP, Xiao Z, Cilz NI, et al. Bombesin facilitates GABAergic transmission and depresses epileptiform activity in the entorhinal cortex. Hippocampus. 2014 Jan;24(1):21-31. PMID: 23966303.

Okarvi SM, Jammaz IA. Preparation and evaluation of bombesin peptide derivatives as potential tumor imaging agents: effects of structure and composition of amino acid sequence on in vitro and in vivo characteristics. Nucl Med Biol. 2012 Aug;39(6):795-804. PMID: 22381782.

Assimakopoulos SF, Tsamandas AC, Alexandris IH, et al. Stimulation of oval cell and hepatocyte proliferation by exogenous bombesin and neurotensin in partially hepatectomized rats. World J Gastrointest Pathophysiol. 2011 Dec 15;2(6):146-54. PMID: 22180848.

Zogovic B, Pilowsky PM. Intrathecal bombesin is sympathoexcitatory and pressor in rat. Am J Physiol Regul Integr Comp Physiol. 2011 Nov;301(5):R1486-94. PMID: 21849634.

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