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Tyrphostin A25 is an inhibitor of EGFR and other various tyrosine kinases. Tyrphostin A25 also inhibits small conductance Ca2+-activates K+ (SK) channels. Tyrphostin A25 is used in research models to examine the effects of various tyrosine kinases.
| Cas No. | 118409-58-8 |
|---|---|
| Purity | ≥98% |
| Formula | C10H6N2O3 |
| Formula Wt. | 202.17 |
| Chemical Name | (3,4,5-Trihydroxybenzylidene)malononitrile |
| IUPAC Name | 2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile |
| Synonym | Tyrphostin 25, RG-50875 |
| Melting Point | 247-248°C |
| Solubility | Soluble in DMSO or ethanol. |
| Appearance | Orange Solid |
| Store Temp | 4°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Wu W, Sun HY, Deng XL, et al. EGFR tyrosine kinase regulates human small-conductance Ca2+-activated K+ (hSKCa1) channels expressed in HEK-293 cells. Biochem J. 2013 May 15;452(1):121-9. PMID: 23496660.
Nguyen J, Gogusev J, Knapnougel P, et al. Protein tyrosine kinase and p38 MAP kinase pathways are involved in stimulation of matrix metalloproteinase-9 by TNF-alpha in human monocytes. Immunol Lett. 2006 Jul 15;106(1):34-41. PMID: 16720051.