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URB602

URB602

Product ID U682042
Cas No. 565460-15-3
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $57.20 In stock
25 mg $157.40 In stock
100 mg $500.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

URB602 is a monoacylglycerol lipase (MAGL) inhibitor. By inhibiting MAGL, it increases the amount of 2-arachicodonyl glycerol, which is a natural substrate for the cannabinoid receptors. URB602 shows anti-inflammatory properties in mice models, as well as anti-nociceptive properties. It also demonstrates neuroprotective effects in 7-day old rat pups. Pretreatment with URB602 lessened the effect of hypoxia-ischemic brain damage in rat pup models.

Product Info

Cas No.

565460-15-3

Purity

≥98%

Formula

C19H21NO2

Formula Wt.

295.38

Chemical Name

[1,1’-Biphenyl]-3-yl-carbamic acid cyclohexyl ester

IUPAC Name

cyclohexyl N-(3-phenylphenyl)carbamate

Solubility

DMSO (>10 mg/mL)

Appearance

White to off-white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

U682042 MSDS PDF

Info Sheet

U682042 Info Sheet PDF

References

Carloni S, Alonso-Alconada D, Girelli S et al. Pretreatment with the monoacyglycerol lipase inhibitor URB602 protects from the long-term consequences of neonatal hypoxic-ischemic brain injury in rats. Pediatr Res. 2012 Oct;72(4):400-6 PMID: 22821058.

King AR, Duranti A, Totini A et al. URB602 inhibits monoacylglycerol lipase and selectively blocks 2-arachidonylglycerol degradation in intact brain slices. Chem Biol. 2007 Dec;14(12):1357-65. PMID:18096504.

Comelli F, Giagnoni G, Bettoni I et al. The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation. Br J Pharmacol. 2007 Nov;152(5):787-94. PMID:17700715.

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