LKT Labs

Biochemicals for Life Science Research

Usnic Acid

Product ID U7354
Cas No. 125-46-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $81.10 In stock
25 g $262.50 In stock
Bulk Quote

Quicklinks

Description

Usnic acid is a dibenzofuran initially produced by lichens and exhibits antibacterial, anti-angiogenic, and anticancer chemotherapeutic activities. Usnic acid displays antibiotic activity against Mycobacterium tuberculosis. In lung carcinoma cells, usnic acid induces G0/G1 phase cell cycle arrest, downregulates expression of CDK4, CDK6, and cyclin D1, and upregulates expression of p21, resulting in apoptosis. Usnic acid also inhibits breast cancer tumor growth and angiogenesis in vivo.

Product Info

Cas No.

125-46-2
Purity

≥98%
Formula

C18H16O7
Formula Wt.

344.32
Chemical Name

2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bh)- dibenzofurandione

IUPAC Name

2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
Synonym

Uanic acid, Usninic acid, Usnein

Melting Point

204°C
Solubility

Soluble water (1.1 mg/mL), acetone (7.7 mg/mL), ethyl acetate (0.88 mg/mL) or ethanol.

Appearance

Grey-yellow Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

U7354 MSDS PDF
Info Sheet

U7354 Info Sheet PDF

References

Singh N, Nambiar D, Kale RK, et al. Usnic acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells. Nutr Cancer. 2013;65 Suppl 1:36-43. PMID: 23682781.

Song Y, Dai F, Zhai D, et al. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. Angiogenesis. 2012 Sep;15(3):421-32. PMID: 22669534.

Ramos DF, Almeida da Silva PE. Antimycobacterial activity of usnic acid against resistant and susceptible strains of Mycobacterium tuberculosis and non-tuberculous mycobacteria. Pharm Biol. 2010 Mar;48(3):260-3. PMID: 20645810.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T291321

    Thiamine Mononitrate

    Vitamin B1

    ≥98%
  • M3368

    Mirtazapine

    Piperazine; 5-HT1 agonist, 5-HT2/3 and α2-adre...

    ≥98%
  • A1202

    Adapalene

    Tretinoin analog; RARα/β/γ agonist.

    ≥98%
  • S8005

    Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • T5996

    Tozasertib

    AurK, FLT3, Abl inhibitor.

    ≥98%
  • E537333

    Enniatin A1

    Mycotoxin contaminant found in cereal grains.

    ≥98%
  • M184774

    5-(Methylsulfinyl)pentyl Nitrile

    Synthetic compound related to sulforaphane.

    ≥98%
  • O4102

    Okadaic Acid Ammonium

    Shellfish toxin produced by dinoflagellates and...

    ≥98%
  • P6859

    Proctolin

    Neuropeptide found in crustaceans and insects.<...

    ≥95%
  • D3320

    Difenoconazole

    Triazole; 14-α demethylase inhibitor, potentia...

    ≥98%
  • G3359

    Ginkgolide J

    Terpene lactone found in Ginkgo.

    ≥98%
  • N1610

    Necrostatin-1

    RIP1 inhibitor.

    ≥99%
  • L589940

    LOXO-101

    Inhibitor of tropomyosin kinase receptors TRKA,...

    ≥99%
  • B011460

    Baloxavir Marboxil

    Cap-dependent endonuclease inhibitor

    ≥ 99%
  • O2146

    R-(+)-Ofloxacin

    Fluoroquinolone, optically active isomer of ofl...

    ≥98%
  • P0146

    Palmitoyl-L-carnitine

    Long chain acylcarnitine involved in fatty acid...

    ≥98%
  • U8000

    U-74389G

    Antioxidant shown to improve renal function.

    ≥95%
  • C0221

    Caffeine

    Xanthine alkaloid found in coffee, tea, and oth...

    ≥98%
  • I0481

    Ibuprofen

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • B030960

    BAY-1082439

    PI3K inhibitor.

    ≥98%