LKT Labs

Biochemicals for Life Science Research

Usnic Acid

Usnic Acid

Product ID U7354
Cas No. 125-46-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $85.20 In stock
25 g $275.60 In stock
Bulk Quote

Quicklinks

Description

Usnic acid is a dibenzofuran initially produced by lichens and exhibits antibacterial, anti-angiogenic, and anticancer chemotherapeutic activities. Usnic acid displays antibiotic activity against Mycobacterium tuberculosis. In lung carcinoma cells, usnic acid induces G0/G1 phase cell cycle arrest, downregulates expression of CDK4, CDK6, and cyclin D1, and upregulates expression of p21, resulting in apoptosis. Usnic acid also inhibits breast cancer tumor growth and angiogenesis in vivo.

Product Info

Cas No.

125-46-2
Purity

≥98%
Formula

C18H16O7
Formula Wt.

344.32
Chemical Name

2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bh)- dibenzofurandione

IUPAC Name

2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
Synonym

Uanic acid, Usninic acid, Usnein

Melting Point

204°C
Solubility

Soluble water (1.1 mg/mL), acetone (7.7 mg/mL), ethyl acetate (0.88 mg/mL) or ethanol.

Appearance

Grey-yellow Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

U7354 MSDS PDF
Info Sheet

U7354 Info Sheet PDF

References

Singh N, Nambiar D, Kale RK, et al. Usnic acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells. Nutr Cancer. 2013;65 Suppl 1:36-43. PMID: 23682781.

Song Y, Dai F, Zhai D, et al. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. Angiogenesis. 2012 Sep;15(3):421-32. PMID: 22669534.

Ramos DF, Almeida da Silva PE. Antimycobacterial activity of usnic acid against resistant and susceptible strains of Mycobacterium tuberculosis and non-tuberculous mycobacteria. Pharm Biol. 2010 Mar;48(3):260-3. PMID: 20645810.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E6245

    Eplerenone

    Mineralocorticoid antagonist.

    ≥99%
  • T3585

    Tivozanib

    VEGFR1/2/3, c-Kit, PDGFR inhibitor.

    ≥98%
  • C5655

    α-Conotoxin GI

    Peptide toxin found in Conus snails; nAChR inhi...

    ≥95%
  • E7857

    Etofenamate

    NSAID; COX-1/2 and lipoxygenase inhibitor.

    ≥98%
  • M3353

    Minocycline Hydrochloride

    Tetracycline; protein translation inhibitor, MM...

    ≥98%
  • A4924

    AMG-208

    c-MET and Ron inhibitor.

    ≥98%
  • S9775

    Systemin

    Peptide hormone found in Solanaceae family plan...

    ≥95%
  • S6018

    Spectinomycin Dihydrochloride Pentahydrate

    Aminocyclitol; protein synthesis inhibitor. &nb...
    ≥603 µg/mg (potency)
  • G0247

    2″O-Galloylhyperin

    Flavonoid glycoside found in Pyrola.

    ≥98%
  • H0207

    Hepatitis B Virus Core Protein (128-140)

    B cell epitope found on hepatitis B viral core ...

    ≥95%
  • N1769

    Nerolidol, synthetic

    AChE inhibitor, F0F1-ATP synthase modulator.

    A mixture of cis and trans isomers, ≥96%
  • G3358

    Ginkgolide ABC

    Mixture of Ginkgolides A, B and C, found in Gin...

    ≥98%
  • S8005

    Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • Z1216

    Z-DEVD-AMC

    Caspase substrate.
    ≥95%
  • T1004

    Paclitaxel Oxetane Ring-Opened 3-Acetyl 4-Benzoyl Impurity

    Synthesis impurity

    ≥92%
  • C3374

    Cisplatin

    Pt-based DNA cross-linker.  
    ≥99%
  • E6376

    Eptifibatide

    Glycoprotein IIb/IIIa inhibitor.

    ≥98%
  • N3496

    Nizatidine

    Histamine H2 inverse agonist.

    ≥98%
  • I0416

    Iberin

    Isothiocyanate found in cruciferous vegetables,...

    ≥97%
  • C9677

    Cyclocytidine Hydrochloride

    Pyrimidine nucleoside analog; DNA synthesis inh...

    ≥98%