LKT Labs

Biochemicals for Life Science Research

Usnic Acid

Usnic Acid

Product ID U7354
Cas No. 125-46-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $85.20 In stock
25 g $275.60 In stock
Bulk Quote

Quicklinks

Description

Usnic acid is a dibenzofuran initially produced by lichens and exhibits antibacterial, anti-angiogenic, and anticancer chemotherapeutic activities. Usnic acid displays antibiotic activity against Mycobacterium tuberculosis. In lung carcinoma cells, usnic acid induces G0/G1 phase cell cycle arrest, downregulates expression of CDK4, CDK6, and cyclin D1, and upregulates expression of p21, resulting in apoptosis. Usnic acid also inhibits breast cancer tumor growth and angiogenesis in vivo.

Product Info

Cas No.

125-46-2
Purity

≥98%
Formula

C18H16O7
Formula Wt.

344.32
Chemical Name

2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bh)- dibenzofurandione

IUPAC Name

2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
Synonym

Uanic acid, Usninic acid, Usnein

Melting Point

204°C
Solubility

Soluble water (1.1 mg/mL), acetone (7.7 mg/mL), ethyl acetate (0.88 mg/mL) or ethanol.

Appearance

Grey-yellow Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

U7354 MSDS PDF
Info Sheet

U7354 Info Sheet PDF

References

Singh N, Nambiar D, Kale RK, et al. Usnic acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells. Nutr Cancer. 2013;65 Suppl 1:36-43. PMID: 23682781.

Song Y, Dai F, Zhai D, et al. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. Angiogenesis. 2012 Sep;15(3):421-32. PMID: 22669534.

Ramos DF, Almeida da Silva PE. Antimycobacterial activity of usnic acid against resistant and susceptible strains of Mycobacterium tuberculosis and non-tuberculous mycobacteria. Pharm Biol. 2010 Mar;48(3):260-3. PMID: 20645810.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • J0274

    Jasplakinolide

    Marine toxin; actin polymerization inducer.

    ≥98%
  • M577521

    Monascorubrin

    Bulgarialactone azaphilone

    ≥98%
  • B3275

    Bis(3,5-dibromosalicyl) Succinate

    Aspirin analog; hemoglobin chain cross-linker.<...

    ≥95%
  • O4417

    Oleanolic Acid

    Triterpenoid found in Vigna angularis and Trigo...

    ≥98%
  • A985136

    AZD5991

    Mcl-1 inhibitor

    ≥99%
  • Z5645

    Zoledronate Disodium Tetrahydrate

    Bisphosphonate; FPPS inhibitor.

    ≥98%
  • B8073

    4-tert-Butyl-5-Methoxycatechol

    BHA derivative.

    ≥98%
  • B6998

    Bryostatin 1

    Macrolide lactone found in Bugula; TLR4 activat...

    ≥98%
  • A4498

    Alytesin

    Antimicrobial peptide found in amphibians.

    ≥95%
  • A7204

    AS-605240

    p110δ PI3K inhibitor.

    ≥98%
  • K0021

    K252a

    Staurosporine analog; PKC inhibitor, TrkA/B ant...

    ≥98%
  • SC7056

    Snake venom – Crotalus durissus terrificus

    Snake venom found in Crotalus durrisus terrific...

    ≥98%
  • L5658

    Lonidamine

    Hexokinase inhibitor, aerobic glycolysis inhibi...

    ≥98%
  • C1876

    Cetirizine Dihydrochloride

    Histamine H1 antagonist.

    ≥99%
  • A9708

    AZD-1208

    Pim-1 inhibitor.

    ≥98%
  • T0098

    10-Deacetyltaxol C

    Diterpene found in Taxus; potential microtubule...

    ≥97%
  • F4557

    Floxuridine

    5-Fluorouracil derivative, fluorinated pyrimidi...

    ≥98%
  • R1724

    Regadenoson

    Adenosine A2A agonist.

    ≥99%
  • E5202

    Enalapril

    ACE inhibitor.

    ≥98%
  • B8277

    Butein

    Flavonoid found in Rhus verniciflua and Butea m...

    ≥99%