LKT Labs

Biochemicals for Life Science Research

Usnic Acid

Usnic Acid

Product ID U7354
Cas No. 125-46-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $85.20 In stock
25 g $275.60 In stock
Bulk Quote

Quicklinks

Description

Usnic acid is a dibenzofuran initially produced by lichens and exhibits antibacterial, anti-angiogenic, and anticancer chemotherapeutic activities. Usnic acid displays antibiotic activity against Mycobacterium tuberculosis. In lung carcinoma cells, usnic acid induces G0/G1 phase cell cycle arrest, downregulates expression of CDK4, CDK6, and cyclin D1, and upregulates expression of p21, resulting in apoptosis. Usnic acid also inhibits breast cancer tumor growth and angiogenesis in vivo.

Product Info

Cas No.

125-46-2
Purity

≥98%
Formula

C18H16O7
Formula Wt.

344.32
Chemical Name

2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bh)- dibenzofurandione

IUPAC Name

2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
Synonym

Uanic acid, Usninic acid, Usnein

Melting Point

204°C
Solubility

Soluble water (1.1 mg/mL), acetone (7.7 mg/mL), ethyl acetate (0.88 mg/mL) or ethanol.

Appearance

Grey-yellow Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

U7354 MSDS PDF
Info Sheet

U7354 Info Sheet PDF

References

Singh N, Nambiar D, Kale RK, et al. Usnic acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells. Nutr Cancer. 2013;65 Suppl 1:36-43. PMID: 23682781.

Song Y, Dai F, Zhai D, et al. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. Angiogenesis. 2012 Sep;15(3):421-32. PMID: 22669534.

Ramos DF, Almeida da Silva PE. Antimycobacterial activity of usnic acid against resistant and susceptible strains of Mycobacterium tuberculosis and non-tuberculous mycobacteria. Pharm Biol. 2010 Mar;48(3):260-3. PMID: 20645810.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D509921

    DMXAA

    Mouse selective STING agonist.

    ≥99%
  • C0374

    β-Casomorphin, human

    Peptide, casein fragment.

    ≥95%
  • O9702

    Ozagrel Hydrochloride

    TxA2 synthase inhibitor.

    ≥98%
  • M174446

    Meleagrin

    FabI inhibitor

    ≥99%
  • T3585

    Tivozanib

    VEGFR1/2/3, c-Kit, PDGFR inhibitor.

    ≥98%
  • A5130

    Amphotericin B

    Polyene, binds ergosterol and induces membrane ...

    ≥90%
  • R3477

    Ritodrine Hydrochloride

    Phenylethylamine; β2-adrenergic agonist, SK/BK...

    ≥98%
  • S0133

    Saikosaponin C

    Triterpene saponin found in Bupleurum.

    ≥98%
  • F5770

    Formononetin

    Isoflavone found in legumes such as soy.

    ≥90%
  • C1635

    Ceftazidime Hydrate

    β-lactam cephalosporin; penicillin binding pro...

    ≥97%
  • H9620

    7-Hydroxyaristolochic Acid A

    Derivative of aristolochic acid found in Asarum...

    ≥95%
  • C9670

    Cyromazine

    Triazine, melamine derivative, insect growth re...

    ≥98%
  • A5061

    Ampalex

    Benzylpiperidine; AMPA potentiator.

    ≥98%
  • D1627

    Dehydrocostus Lactone

    Sesquiterpene lactone found in Saussurea.

    ≥98%
  • D6957

    Droloxifene

    Triphenylthylene, tamoxifen analog; SERM.

    ≥98%
  • P3463

    Piperacillin Sodium

    β-lactam; penicillin binding protein inhibitor...

    ≥95%
  • E6846

    Erlotinib Hydrochloride

    EGFR inhibitor.

    ≥98%
  • S4244

    SKLB 610

    VEGFR2, PDGFR, FGFR2 inhibitor.

    ≥98%
  • N1755

    Neomycin Sulfate

    Polycationic aminoglycoside; protein translatio...

    ≥98%
  • A5280

    Angiotensin II (3-8), human

    Endogenous peptide fragment, involved in vasoco...

    ≥95%