LKT Labs

Biochemicals for Life Science Research

Usnic Acid

Usnic Acid

Product ID U7354
Cas No. 125-46-2
Purity ≥98%
Product Unit SizeCostQuantityStock
5 g $85.20 In stock
25 g $275.60 In stock
Bulk Quote

Quicklinks

Description

Usnic acid is a dibenzofuran initially produced by lichens and exhibits antibacterial, anti-angiogenic, and anticancer chemotherapeutic activities. Usnic acid displays antibiotic activity against Mycobacterium tuberculosis. In lung carcinoma cells, usnic acid induces G0/G1 phase cell cycle arrest, downregulates expression of CDK4, CDK6, and cyclin D1, and upregulates expression of p21, resulting in apoptosis. Usnic acid also inhibits breast cancer tumor growth and angiogenesis in vivo.

Product Info

Cas No.

125-46-2
Purity

≥98%
Formula

C18H16O7
Formula Wt.

344.32
Chemical Name

2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyl-1,3(2H,9bh)- dibenzofurandione

IUPAC Name

2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
Synonym

Uanic acid, Usninic acid, Usnein

Melting Point

204°C
Solubility

Soluble water (1.1 mg/mL), acetone (7.7 mg/mL), ethyl acetate (0.88 mg/mL) or ethanol.

Appearance

Grey-yellow Powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

U7354 MSDS PDF
Info Sheet

U7354 Info Sheet PDF

References

Singh N, Nambiar D, Kale RK, et al. Usnic acid inhibits growth and induces cell cycle arrest and apoptosis in human lung carcinoma A549 cells. Nutr Cancer. 2013;65 Suppl 1:36-43. PMID: 23682781.

Song Y, Dai F, Zhai D, et al. Usnic acid inhibits breast tumor angiogenesis and growth by suppressing VEGFR2-mediated AKT and ERK1/2 signaling pathways. Angiogenesis. 2012 Sep;15(3):421-32. PMID: 22669534.

Ramos DF, Almeida da Silva PE. Antimycobacterial activity of usnic acid against resistant and susceptible strains of Mycobacterium tuberculosis and non-tuberculous mycobacteria. Pharm Biol. 2010 Mar;48(3):260-3. PMID: 20645810.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T0102

    7-epi-Taxol

    Taxane found in Taxus; potential microtubule de...

    ≥95%
  • M0803

    MC1568

    HDAC inhibitor. May reduce blood pressure in hy...

    ≥98%
  • C3214

    CID-797718

    Potential PKD binding agent.

    ≥99%
  • I5315

    Indomethacin

    NSAID; COX-1/2 inhibitor.

    ≥98%
  • S1846

    Selumetinib

    MEK1/2 inhibitor.

    ≥99%
  • V3327

    Virginiamycin Mixture

    Macrolide antibiotic

    ≥97%
  • A4802

    Amantadine Hydrochloride

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • C9614

    Cyclosporin H

    Cyclosporin metabolite; formyl peptide inhibito...

    ≥96%
  • A4933

    Amifostine Trihydrate

    Thiol prodrug, antioxidant.

    ≥98%
  • I761004

    Itaconic Acid

    Polymer precursor

    ≥99%
  • P7059

    Proxymetacaine Hydrochloride

    Potential voltage-gated Na+ channel blocker.

    ≥98%
  • D3352

    Dinaciclib

    BRD binding agent, CDK1/2/5/9 inhibitor.

    ≥99%
  • D0005

    Dabrafenib Mesylate

    B-Raf and c-Raf inhibitor.

    ≥98%
  • A5276

    Angiotensin I, human

    Endogenous peptide, cleavage product of angiote...

    ≥98%
  • S584780

    Sotorasib racemate

    KRAS inhibitor

    ≥99%
  • L3454

    Lincomycin Hydrochloride Monohydrate

    Lincosamide; peptidyl transferase inhibitor, pr...

    ≥98%
  • T5060

    TMP-269

    HDAC inhibitor.

    ≥98%
  • T6831

    Triadimenol

    Triadimefon metabolite; mutagen.

    ≥96%
  • H9712

    (E)-4-Hydroxytamoxifen

    SERM.

    ≥97%
  • N7200

    NS-11394

    GABA-A α5/3/2 positive modulator.

    ≥98%