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Valnemulin Hydrochloride

Valnemulin Hydrochloride

Product ID V014457
Cas No. 133868-46-9
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $52.50 In stock
100 mg $150.40 In stock
250 mg $277.90 In stock
1 g $630.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Valnemulin hydrochloride is a pleuromutilin antibiotic derivative with anti-inflammatory activities. In cell line RAW264.7, valmenulin inhibited nitric oxide, prostaglandin E2, and tumor necrosis factor-alpha. In a mouse model of lung injury, valnemulin was found to decrease tissue injury and inflammation. Furthermore, a study on Staphylococcus aureus found valnemulin to give prolonged postantibiotic effects.

Product Info

Cas No.

133868-46-9

Purity

≥98%

Formula

C31H52N2O5S • HCl

Formula Wt.

601.28

IUPAC Name

(1S,2R,3S,4S,6R,7R,8R,14R)-3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.01,8]tetradec-6-yl {[2-methyl-1-(D-valylamino)-2-propanyl]sulfanyl}acetate hydrochloride (1:1)

Synonym

Valnemulin HCl

Solubility

Soluble in ethanol, methanol, DMF, DMSO. Slightly soluble in water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V014457 MSDS PDF

Info Sheet

V014457 Info Sheet PDF

References

Poulsen SM, Karlsson M, Johansson LB, et al. The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome. Mol Microbiol, 2001 Sep;41(5):1091-1099. PMID: 11555289.

Zhang X, Li H, Xiong H, et al. Valnemulin downregulates nitric oxide, prostaglandin E2, and cytokine production via inhibition of NF-kappaB and MAPK activity. Int Immunopharmacol. 2009 Jul;9(7-8):810-816. PMID: 19293003.

Chen Z, Zhang X, Chu X, et al. Preventive effects of valnemulin on lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2010 Oct;33(5):306-314. PMID: 20221680.

Zhao DH, Yu Y, Zhou YF, et al. Postantibiotic effect and postantibiotic sub-minimum inhibitory concentration effect of valnemulin against Staphylococcus aureus isolates from swine and chickens. Lett Appl Microbiol. 2014 Feb;58(2):150-155. PMID: 24117872.

Custom Order

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