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Verapamil is an inhibitor of L-type voltage-gated Ca2+ channels that exhibits antihypertensive, anti-arrhythmic, and cardioprotective activities; it is classified as a class IV anti-arrhythmic. Verapamil treats hypertension and ventricular arrhythmia. In experiencing myocardial infarction, verapamil decreases secondary infarction rates.
| Cas No. | 152-11-4 |
|---|---|
| Purity | ≥98% |
| Formula | C27H38N2O4 • HCl |
| Formula Wt. | 491.07 |
| Chemical Name | α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]- propyl]-3,4-dimethoxy-α-(1-methylethyl)benzene- acetonitrile |
| IUPAC Name | 2-(3,4-dimethoxyphenyl)-5-[2-(3, 4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile; hydrochloride |
| Synonym | Arpamyl, Berkatens, Calan, Cardiagutt, Cordilox, Dignover, Geangin, Univer, Veraptin, Verexamil |
| Melting Point | 138.5-140.5°C(dec.) |
| Solubility | Soluble in water, propylene glycol, methanol, or methylene chloride. |
| Appearance | White powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Flynn JT, Pasko DA. Calcium channel blockers: pharmacology and place in therapy of pediatric hypertension. Pediatr Nephrol. 2000 Dec;15(3-4):302-16. PMID: 11149130.
Pepine CJ. The role of calcium antagonists in ischaemic heart disease. Eur Heart J. 1995 Aug;16 Suppl H:19-24. PMID: 8846801.