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Verruculogen

Verruculogen

Product ID V1870
Cas No. 12771-72-1
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $202.70 In stock
5 mg $840.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Verruculogen is a mycotoxin initially produced by species of Aspergillus; it is considered a tremorgenic indole alkaloid and may induce development of neurological disorders. Verruculogen inhibits Ca2+-activated K+ (BK) channels and may also act as an antagonist on GABA-A receptors, binding at or near the Cl- channel.

Product Info

Cas No.

12771-72-1

Purity

≥95%

Formula

C27H33N3O7

Formula Wt.

511.57

IUPAC Name

(9R,14S,17S,23R,24S)-23,24-dihydroxy-5-methoxy-12,12-dimethyl-9-(2-methylprop-1-enyl)-10,11-dioxa-8,15,21-triazahexacyclo[12.10.1.02,7.08,25.015,23.017,21]pentacosa-1(25),2(7),3,5-tetraene-16,22-dione

Synonym

NA 209A, TR1

Melting Point

230-233°C

Solubility

DMSO, Methanol, Ethanol

Appearance

White Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

V1870 MSDS PDF

Info Sheet

V1870 Info Sheet PDF

References

Smith RC, McClure MC, Smith MA, et al. The role of voltage-gated potassium channels in the regulation of mouse uterine contractility. Reprod Biol Endocrinol. 2007 Nov 2;5:41. PMID: 17980032.

Kosalec I, Klarić MS, Pepeljnjak S. Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres. Acta Pharm. 2005 Dec;55(4):357-64. PMID: 16375825.

Knaus HG, McManus OB, Lee SH, et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry. 1994 May 17;33(19):5819-28. PMID: 7514038.

Gant DB, Cole RJ, Valdes JJ, et al. Action of tremorgenic mycotoxins on GABAA receptor. Life Sci. 1987 Nov 9;41(19):2207-14. PMID: 2444852.

Custom Order

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