LKT Labs

Biochemicals for Life Science Research

Vidarabine

Vidarabine

Product ID V3212
Cas No. 5536-17-4
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $71.50 In stock
500 mg $183.60 In stock
1 g $255.30 In stock
Bulk Quote

Quicklinks

Description

Vidarabine is a long-acting antiviral originally found in the marine sponge Tethyra crypta. Vidarabine is an adenosine analog in which the D-ribose constituent is replaced by D-arabinose, preventing formation of phosphodiester bridges upon incorporation into DNA. This compound is a substrate for and inhibitor of viral DNA polymerase and may also inhibit ribonucleotide reductase. Vidarabine is used to treat subjects with severe chronic Epstein-Barr virus, herpes simplex virus, or human papilloma virus, as well as immunocompromised patients with adenovirus-induced hemorrhagic cystitis.

Product Info

Cas No.

5536-17-4
Purity

≥98%
Formula

C10H13N5O4
Formula Wt.

267.24
Chemical Name

9-β-D-Aribinofuranosyl-9H-purine-6-amine monohydrate
IUPAC Name

(2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Synonym

Arabinosyladenine, Adenine Arabinoside, Spongoadenosine, Ara-A, Arasena-A, Vira-A
Melting Point

257-257.5°C
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

V3212 MSDS PDF
Info Sheet

V3212 Info Sheet PDF

References

Whitley RJ. The use of antiviral drugs during the neonatal period. Clin Perinatol. 2012 Mar;39(1):69-81. PMID: 22341538.

Wilhelmus KR. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD002898. PMID: 21154352.

Sagar S, Kaur M, Minneman KP. Antiviral lead compounds from marine sponges. Mar Drugs. 2010 Oct 11;8(10):2619-38. PMID: 21116410.

Kurosaki K, Miwa N, Yoshida Y, et al. Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir Chem Chemother. 2004 Sep;15(5):281-5. PMID: 15535050.

Niwa K, Tagami K, Lian Z, et al. Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions. Oncol Rep. 2003 Sep-Oct;10(5):1437-41. PMID: 12883720.

Kimura H, Morita M, Tsuge I, et al. Vidarabine therapy for severe chronic active Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2001 Jun-Jul;23(5):294-9. PMID: 11464986.

Nimit Y, Law J, Daly JW. Binding of 2',5'-dideoxyadenosine to brain membranes. Comparison to P-site inhibition of adenylate cyclase. Biochem Pharmacol. 1982 Oct 15;31(20):3279-87. PMID: 6983353.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A0002

    A66

    p110α PI3K inhibitor.

    ≥98%
  • T2792

    TGX-221

    p110β PI3K inhibitor.
  • C022682

    2-Carbomethoxy-3-thiophenesulfonyl Chloride

    Building block

    ≥98%
  • E5477

    Entinostat

    Benzamide; HDAC1 inhibitor.

    ≥98%
  • D0011

    Dacarbazine

    DNA alkylator.

    ≥98%
  • C2957

    Cholesterol

    Endogenous sterol component of animal cell memb...

    ≥97%
  • P0392

    Paxilline

    Neuroactive mycotoxin produced by Penicillum an...

    ≥98%
  • B8174

    Butylated Hydroxyanisole

    Commercial food additive, antioxidant.

    ≥96%
  • C344761

    Citalopram Chloromethyl Quaternary Ammonium Chloride

    Citalopram analog

    ≥95%
  • C9808

    CZC-54252

    LRRK2 inhibitor.

    ≥98%
  • C1668

    Cerivastatin Sodium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • C0275

    Castanospermine

    O-GlcNAcase inhibitor.

    ≥98%
  • R3577

    Ritonavir

    HIV protease inhibitor.

    ≥98%
  • A2050

    Aflatoxin G2

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • P6977

    Pyr-GR-pNA

    Fluorogenic substrate used to measure serine pr...

    ≥98%
  • D5746

    Dolasetron

    5-HT3 antagonist.

    ≥98%
  • D1773

    Deshydroxy LY-411575

    γ-Secretase inhibitor.

    ≥98%
  • D1850

    Demethoxycurcumin

    Curcumin derivative; AMPK activator, STAT3 and ...

    ≥98%
  • P0008

    Pituitary Adenylate Cyclase-activating Peptide (6-38), human/sheep/rat

    Endogenous peptide, involved in paracrine and a...

    ≥95%
  • A6268

    Aprotinin

    Polypeptide; serine protease inhibitor.

    ≥ 5400 u/mg