Vidarabine

Name: Vidarabine
SKU: V3212
Availability: InStock

Product ID V3212

Cas No. 5536-17-4

Purity ≥98%

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Description

Vidarabine is a long-acting antiviral originally found in the marine sponge Tethyra crypta. Vidarabine is an adenosine analog in which the D-ribose constituent is replaced by D-arabinose, preventing formation of phosphodiester bridges upon incorporation into DNA. This compound is a substrate for and inhibitor of viral DNA polymerase and may also inhibit ribonucleotide reductase. Vidarabine is used to treat subjects with severe chronic Epstein-Barr virus, herpes simplex virus, or human papilloma virus, as well as immunocompromised patients with adenovirus-induced hemorrhagic cystitis.

Product Info

Cas No.	5536-17-4
Purity	≥98%
Formula	C₁₀H₁₃N₅O₄
Formula Wt.	267.24
Chemical Name	9-β-D-Aribinofuranosyl-9H-purine-6-amine monohydrate
IUPAC Name	(2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Synonym	Arabinosyladenine, Adenine Arabinoside, Spongoadenosine, Ara-A, Arasena-A, Vira-A
Melting Point	257-257.5°C
Appearance	White Crystal Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	V3212 MSDS PDF
Info Sheet	V3212 Info Sheet PDF

References

Whitley RJ. The use of antiviral drugs during the neonatal period. Clin Perinatol. 2012 Mar;39(1):69-81. PMID: 22341538.

Wilhelmus KR. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD002898. PMID: 21154352.

Sagar S, Kaur M, Minneman KP. Antiviral lead compounds from marine sponges. Mar Drugs. 2010 Oct 11;8(10):2619-38. PMID: 21116410.

Kurosaki K, Miwa N, Yoshida Y, et al. Therapeutic basis of vidarabine on adenovirus-induced haemorrhagic cystitis. Antivir Chem Chemother. 2004 Sep;15(5):281-5. PMID: 15535050.

Niwa K, Tagami K, Lian Z, et al. Topical vidarabine or 5-fluorouracil treatment against persistent HPV in genital (pre)cancerous lesions. Oncol Rep. 2003 Sep-Oct;10(5):1437-41. PMID: 12883720.

Kimura H, Morita M, Tsuge I, et al. Vidarabine therapy for severe chronic active Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2001 Jun-Jul;23(5):294-9. PMID: 11464986.

Nimit Y, Law J, Daly JW. Binding of 2',5'-dideoxyadenosine to brain membranes. Comparison to P-site inhibition of adenylate cyclase. Biochem Pharmacol. 1982 Oct 15;31(20):3279-87. PMID: 6983353.

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Vidarabine

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