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Vincristine is a vinca alkaloid found in Catharanthus that exhibits immunosuppressive and anticancer chemotherapeutic activities. Vincristine is an anti-mitotic that binds tubulin and inhibits microtubule polymerization; it is clinically used to treat lymphomas and leukemias and is one component of the CHOP chemotherapy cocktail. In melanoma cells, vincristine increases activation of AMPK and inhibition of mTORC1 signaling.
| Cas No. | 2068-78-2 |
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| Purity | ≥98% |
| Formula | C46H56N4O10 • H2O4S |
| Formula Wt. | 923.05 |
| Chemical Name | 22-Oxovincaleukoblastine sulfate |
| IUPAC Name | methyl (1R,9R,10S,11R,12R,19R)-11-acetyloxy-12-ethyl-4-[(13S,15S,17S)-17-ethyl-17-hydroxy-13-methoxycarbonyl-1,11-diazatetracyclo[13.3.1.04,12.05,10]nonadeca-4(12),5,7,9-tetraen-13-yl]-8-formyl-10-hydroxy-5-methoxy-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraene-10-carboxylate;sulfuric acid |
| Synonym | Kyocristine, Oncovin, Vincrex |
| Melting Point | 273-281°C |
| Solubility | Soluble in water (50 mg/mL), methanol (20 mg/mL), PBS (2 mg/mL). Slightly soluble in ethanol or chloroform. |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Wang L, Xia ZJ, Huang HQ, et al. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of stage IE/IIE extranodal natural killer/T cell lymphoma, nasal type: 13-year follow-up in 135 patients. Int J Hematol. 2012 Nov;96(5):617-23. PMID: 22983648.
Chen MB, Shen WX, Yang Y, et al. Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell. J Cell Physiol. 2011 Jul;226(7):1915-25. PMID: 21506122.
Jordan MA, Wilson L. Microtubules as a target for anticancer drugs. Nat Rev Cancer. 2004 Apr;4(4):253-65. PMID: 15057285.