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Voglibose

Voglibose

Product ID V5725
Cas No. 83480-29-9
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $97.70 In stock
10 mg $171.30 In stock
25 mg $339.70 In stock
100 mg $1,006.20 In stock
Bulk Quote

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  • Product Info
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  • References
  • Description
  • Product Info
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Description

Voglibose is an inhibitor of α-glucosidase that exhibits anti-diabetic, anti-hyperglycemic, anti-hyperlipidemic, anti-melanogenic, and cardioprotective benefits. In obese mice, voglibose increases plasma levels of glucagon-like peptide 1 (GLP-1), indirectly decreasing activity of DPP4. Additionally, voglibose decreases expression of intracellular adhesion molecule 1 (ICAM-1) and excretion of C-reactive protein (CRP), also decreasing oxidative stress. In clinical studies, voglibose improves body mass index and hemoglobin A(1c) values and decreases hyperlipidemia and hyperglycemia. Inhibition of α-glucosidase also blocks N-glycan modification of tyrosinase, decreasing levels of tyrosinase and melanin. In several animal models of myocardial ischemia/reperfusion, voglibose upregulates phosphorylated Akt and phosphorylated eNOS expression, decreasing myocardial infarction size; this compound may also activate GLP-1 receptors or open mitochondrial K+ (ATP) channels,

Product Info

Cas No.

83480-29-9

Purity

≥99%

Formula

C10H21NO7

Formula Wt.

267.28

Chemical Name

(1S,2S,3R,4S,5S)-5-(1,3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol

IUPAC Name

(1S,2S,3R,4S,5S)-5-(1, 3-dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol

Synonym

Glustat; Basen; AO-128; Vocarb; 3,4-dideoxy-4-((2-hydroxy-1-(hydroxymethyl)ethyl)amino)-2-C-(hydroxymethyl)-D-epi-inositol

Melting Point

162 -164 ℃

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V5725 MSDS PDF

Info Sheet

V5725 Info Sheet PDF

References

Bin BH, Seo J, Yang SH, et al. Novel inhibitory effect of the antidiabetic drug voglibose on melanogenesis. Exp Dermatol. 2013 Aug;22(8):541-6. PMID: 23879813.

Iwasa M, Kobayashi H, Yasuda S, et al. Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits. J Cardiovasc Pharmacol. 2010 Jun;55(6):625-34. Erratum in: J Cardiovasc Pharmacol. 2012 Jul;60(1):108. PMID: 20351564.

Kawamori R, Tajima N, Iwamoto Y, et al. Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance. Lancet. 2009 May 9;373(9675):1607-14. PMID: 19395079.

Moritoh Y, Takeuchi K, Hazama M. Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. J Pharmacol Exp Ther. 2009 May;329(2):669-76. PMID: 19208898.

Satoh N, Shimatsu A, Yamada K, et al. An alpha-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients. Metabolism. 2006 Jun;55(6):786-93. PMID: 16713439.

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