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Voriconazole is a triazole antifungal compound developed specifically to target species of Aspergillus, although it displays broad spectrum activity against other fungi as well. Voriconazole inhibits 14α sterol demethylase (14αSD). This compound also exhibits immunomodulatory activity, as it increases levels of toll-like receptor 2 (TLR2) and TNF-α and stimulates translocation of NF-κB in monocytes.
| Cas No. | 137234-62-9 |
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| Purity | ≥98% |
| Formula | C16H14F3N5O |
| Formula Wt. | 349.31 |
| Chemical Name | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol |
| IUPAC Name | (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2, 4-triazol-1-yl)butan-2-ol |
| Melting Point | 127-130°C |
| Appearance | White to off white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Thompson GR 3rd, Lewis JS 2nd. Pharmacology and clinical use of voriconazole. Expert Opin Drug Metab Toxicol. 2010 Jan;6(1):83-94. PMID: 19947892.
Simitsopoulou M, Roilides E, Paliogianni F, et al. Immunomodulatory effects of voriconazole on monocytes challenged with Aspergillus fumigatus: differential role of Toll-like receptors. Antimicrob Agents Chemother. 2008 Sep;52(9):3301-6. PMID: 18625774.
Varanasi NL, Baskaran I, Alangaden GJ, et al. Novel effect of voriconazole on conidiation of Aspergillus species. Int J Antimicrob Agents. 2004 Jan;23(1):72-9. PMID: 14732317.
