Description
VS-5584 inhibits PI3K and displays anticancer chemotherapeutic activity, inhibiting cell proliferation in a variety of cancer cell lines and suppressing tumor growth in animal models of gastric cancer.
| Product Unit Size | Cost | Quantity | Stock |
|---|
VS-5584 inhibits PI3K and displays anticancer chemotherapeutic activity, inhibiting cell proliferation in a variety of cancer cell lines and suppressing tumor growth in animal models of gastric cancer.
| Cas No. | 1246560-33-7 |
|---|---|
| Purity | ≥98% |
| Formula | C17H22N8O |
| Formula Wt. | 354.41 |
| IUPAC Name | 5-(8-methyl-2-morpholin-4-yl-9-propan-2-ylpurin-6-yl)pyrimidin-2-amine |
| Synonym | SB2343, SB-2343, VS5584 |
| Solubility | DMSO 71 mg/mL (200.33 mM) Ethanol 3 mg/mL (8.46 mM) Water Insoluble |
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
| MSDS | |
|---|---|
| Info Sheet |
Hart S, Novotny-Diermayr V, Goh KC, et al. VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Mol Cancer Ther. 2013 Feb;12(2):151-61. PMID: 23270925.
p110γ PI3K inhibitor.
ACE inhibitor.
Diterpene alkaloid found in Aconitum; voltage-g...
Coumarin; VKORC1 inhibitor.
Epoxide metabolite of acrylamide, induces DNA a...
Endogenous peptide hormone inolved in gastric e...
Triterpenoid found in Centella.
RARα/β agonist.
Tankyrase inhibitor.
CRM1-selective inhibitor of nuclear export.
Arp2/3 inhibitor.
Fluoroquinolone; bacterial DNA gyrase and helic...
Effective against gram-positive pathogens
Endogenous purine derivative of xanthine.
TRPV1 agonist, histamine H1 antagonist.
ACE inhibitor.
Endogenous peptide hormone inolved in gastric e...
5-HT3 antagonist.
Pt-based DNA cross-linker.
Building block