Description
VX-11e inhibits ERK2 and exhibits anticancer activity. VX-11e also displays some inhibitory activity against aurora kinase A (AurA), glycogen synthase kinase 3 (GSK-3), CDK2, FLT3, ROCK1, and JNK3.
VX-11e inhibits ERK2 and exhibits anticancer activity. VX-11e also displays some inhibitory activity against aurora kinase A (AurA), glycogen synthase kinase 3 (GSK-3), CDK2, FLT3, ROCK1, and JNK3.
Cas No. | 896720-20-0 |
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Purity | ≥98% |
Formula | C24H20Cl2FN5O2 |
Formula Wt. | 500.35 |
IUPAC Name | 4-[2-(2-chloro-4-fluoroanilino)-5-methylpyrimidin-4-yl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide |
Synonym | ERK 11e, TCS ERK 11e |
Solubility | DMSO 100 mg/mL (199.86 mM) Ethanol 16 mg/mL (31.97 mM) Water Insoluble |
Appearance | Off-white Powder |
Store Temp | -20°C |
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Ship Temp | Ambient |
MSDS | |
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Info Sheet | |
Brochures |
Aronov AM, Tang Q, Martinez-Botella G, et al. Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J Med Chem. 2009 Oct 22;52(20):6362-8. PMID: 19827834.
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