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VX-11e

VX-11e

Product ID V9201
Cas No. 896720-20-0
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $118.40 In stock
5 mg $236.90 In stock
10 mg $382.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

VX-11e inhibits ERK2 and exhibits anticancer activity. VX-11e also displays some inhibitory activity against aurora kinase A (AurA), glycogen synthase kinase 3 (GSK-3), CDK2, FLT3, ROCK1, and JNK3.

Product Info

Cas No.

896720-20-0

Purity

≥98%

Formula

C24H20Cl2FN5O2

Formula Wt.

500.35

IUPAC Name

4-[2-(2-chloro-4-fluoroanilino)-5-methylpyrimidin-4-yl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide

Synonym

ERK 11e, TCS ERK 11e

Solubility

DMSO 100 mg/mL (199.86 mM) Ethanol 16 mg/mL (31.97 mM) Water Insoluble

Appearance

Off-white Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V9201 MSDS PDF

Info Sheet

V9201 Info Sheet PDF

Brochures

Ras-Raf-MEK-ERK Pathway Booklet

References

Aronov AM, Tang Q, Martinez-Botella G, et al. Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J Med Chem. 2009 Oct 22;52(20):6362-8. PMID: 19827834.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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