• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
VX-765

VX-765

Product ID V9228
Cas No. 273404-37-8
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $147.20 In stock
5 mg $245.10 In stock
10 mg $379.70 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

VX-765 is an inhibitor of NLRP3 inflammasome activity; it inhibits caspase 1 and IL-1β cleavage and release. VX-765 exhibits anti-inflammatory, antidepressant, and antiepileptic activities. In vivo, this compound decreases IL-1β levels and attenuates stress-induced depression-like behaviors. In animal models of status epilepticus, VX-765 decreases cell loss. In other similar animal models, this compound decreases chronic epileptic activity and delays onset of acute seizures.

Product Info

Cas No.

273404-37-8

Purity

≥98%

Formula

C24H33ClN4O6

Formula Wt.

509.00

IUPAC Name

N-(4-Amino-3-chlorobenzoyl)-3-methylvalyl-N-[(2R,3S)-2-ethoxy-5-oxotetrahydro-3-furanyl]-L-prolinamide

Synonym

VX765,Belnacasan

Solubility

DMSO 100 mg/mL warmed (196.46 mM) Ethanol 100 mg/mL warmed (196.46 mM) Water Insoluble

Appearance

Light yellow powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

V9228 MSDS PDF

Info Sheet

V9228 Info Sheet PDF

References

Zhang Y, Liu L, Liu YZ, et al. NLRP3 Inflammasome Mediates Chronic Mild Stress-induced Depression in Mice via Neuroinflammation. Int J Neuropsychopharmacol. 2015 Jan 20. [Epub ahead of print]. PMID: 25603858.

Kaminski RM, Rogawski MA, Klitgaard H. The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments. Neurotherapeutics. 2014 Apr;11(2):385-400. PMID: 24671870.

Noe FM, Polascheck N, Frigerio F, et al. Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy. Neurobiol Dis. 2013 Nov;59:183-93. PMID: 23938763.

Maroso M, Balosso S, Ravizza T, et al. Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice. Neurotherapeutics. 2011 Apr;8(2):304-15. PMID: 21431948.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • R0245

    Raltitrexed

    Folate analog; thymidylate synthase inhibitor.<...

    ≥98%
  • S3345

    Silymarin

    Flavonolignan mixture found in Silybum (milk th...

    ≥50% sylibin
  • V1769

    Verapamil Hydrochloride

    L-type Ca2+ channel blocker.

    ≥98%
  • S3343

    Silybin

    Flavonoid originally found in Silybum (milk thi...

    ≥97%
  • P1764

    Pep-1 Peptide

    Cell-penetrating peptide, carries large conjuga...

    ≥95%
  • N5652

    Nonactin

    Naturally-ocurring neurtral cyclic ionophore, m...

    ≥95%, TLC
  • A9601

    AZD-5363

    AKT inhibitor, potential ROCK, p70S6K, PKA, MKK...

    ≥99%, ≥99%ee
  • S8046

    R-Sulforaphane, High Purity

    Naturally occuring isothiocyanate found in broc...

    ≥98%
  • I4961

    Imperatorin

    Furocoumarin; voltage-gated Na+ channel blocker...

    ≥98%
  • T2936

    Thioridazine Hydrochloride

    Piperadine phenothiazine; FIASMA, D1-5, histami...

    ≥98%
  • A9803

    Azathioprine

    Purine nucleotide analog, mercaptiopurine prodr...

    ≥98%
  • G6817

    Green Tea Polyphenols

    Extract containing catechins and flavonoids fou...

    ≥98%
  • R3249

    Rimantadine Hydrochloride

    Viral M2 proton channel blocker.

    ≥98%
  • I7658

    1-Isothiocyanato-9-(methylsulfonyl)-nonane

    Synthetic ITC, erysolin analog.

    ≥98%
  • F3209

    Fibronectin-Binding Protein

    Peptide, binds fibronectin.

    ≥95%
  • D3447

    Diltiazem Hydrochloride

    Benzothiazepine; L-type Ca2+ channel blocker, p...

    ≥98%
  • M1679

    Methysticin

    Kavalactone originally found in Piper methystic...

    ≥98%
  • P6858

    Procarbazine Hydrochloride

    Hydrazine derivative, DNA alkylator; MAO inhibi...

    ≥97%
  • S7717

    Sterigmatocystin

    Mycotoxin produced by Aspergillus; carcinogen.<...

    ≥98%
  • B3345

    (−)-Bilobalide

    Sesquiterpene lactone found in Ginkgo; GABA-A a...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only