WWL70

Product ID W894440

Cas No. 947669-91-2

Purity ≥95%

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Product Info
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Description
Product Info
Shipping and Storage
Downloads
References
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Description

WWL70 is an inhibitor of the serine hydrolase alpha/beta hydrolase domain 6 (ABHD6). ABHD6 is able to hydrolyze 2-arachidonoyl glycerol(2-AG) to arachidonic acid. WWL70 inhibits this process from occurring, resulting in anti-inflammatory and anti-diabetic results. WWL70 was used to determine the role of ABHD6 in diet induced obese mice. Inhibition of ABHD6 resulted in lower weight gain and less incidence of diabetes in mice. In an LPS system, WWL70 was found to reduce the amount of pro-inflammatory prostaglandins.

Product Info

Cas No.	947669-91-2
Purity	≥95%
Formula	C₂₇H₂₃N₃O₃
Formula Wt.	437.50
Chemical Name	[4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate
IUPAC Name	[4-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-pyridin-4-ylphenyl)methyl]carbamate
Solubility	10mM in DMSO

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	W894440 MSDS PDF
Info Sheet	W894440 Info Sheet PDF

References

Tanaka M, Moran S, Wen J et al. WWL70 attenuates PGE2 production derived from 2-arachidonoylglycerol in microglia by ABHD6-independent mechanism. J Neuroinflammation. 2017 Jan 10;14(1):7. PMID: 28086912.

Zhao S, Mugabo Y, Ballentine G et al. alpha/beta-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes. Cell Rep. 2016 Mar 29;14(12):2872-88. PMID: 26997277.

Alhouayek M, Masquelier J, Cani PD et al. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. Proc Natl Acad Sci USA. 2013 Oct 22;110(43):17558-63. PMID: 24101490.