Yangonin

Name: Yangonin
SKU: Y0052
Availability: InStock

Product ID Y0052

Cas No. 500-62-9

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Yangonin is a dienolide kavalactone originally found in Piper methysticum (kava plant). Yangonin exhibits neuroprotective, neuromodulatory, and antifungal activities. Yangonin activates cannabinoid (CB1) receptors and potentiates the effects of GABA-A receptors. Additionally, yangonin also activates Nrf2 in neurons and astroglia, protecting against amyloid-β (Aβ)-induced neurotoxicity. This compound displays antimicrobial efficacy against species of Fusarium, Trichoderma, and Colletotrichum.

Product Info

Cas No.	500-62-9
Purity	≥98%
Formula	C₁₅H₁₄O₄
Formula Wt.	258.27
Chemical Name	(E)-4-Methoxy-6-[2-(4-methoxyphenyl)ethenyl]-2H- pyran-2-one
IUPAC Name	4-methoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]pyran-2-one
Synonym	4-Methoxy-6-(β-(p-anisyl)vinyl)-α-pyrone
Melting Point	155-157°C
Solubility	Practically insoluble in water. Soluble in hot ethanol (2 mg/mL), DMSO (10 mg/mL), ethyl acetate and acetone. Slightly soluble in benzene or ether.
Appearance	Yellowish/Greenish Crystalline Powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	Y0052 MSDS PDF
Info Sheet	Y0052 Info Sheet PDF

References

Ligresti A, Villano R, Allarà M, et al. Kavalactones and the endocannabinoid system: the plant-derived yangonin is a novel CB1 receptor ligand. Pharmacol Res. 2012 Aug;66(2):163-9. PMID: 22525682.

Wruck CJ, Götz ME, Herdegen T, et al. Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation. Mol Pharmacol. 2008 Jun;73(6):1785-95. PMID: 18334601.

Xuan TD, Elzaawely AA, Fukuta M, et al. Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). J Agric Food Chem. 2006 Feb 8;54(3):720-5. PMID: 16448174.

Boonen G, Häberlein H. Influence of genuine kavapyrone enantiomers on the GABA-A binding site. Planta Med. 1998 Aug;64(6):504-6. PMID: 9776662.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Yangonin

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Pseudoprotodioscin

Nicergoline

Prothionamide

Amitraz

Omeprazole Impurity F and G mixture

PF-06821497

Amorolfine Hydrochloride

Betamethasone Valerate

Streptomycin Sulfate

(−)-Huperzine A

Calcineurin Substrate

3′-Azido-3′-deoxythymidine

Fidaxomicin

Recombinant M. Tuberculosis Antigen TB 38+6+10

Bradykinin Triacetate

N-(4-Hydroxyphenyl)retinamide

Meropenem Trihydrate

Adrenocorticotropic Hormone (1-24), human

Menaquinone-7

Cyclopamine

Footer