Description
Z-Pro-D-Leu is a C-terminal peptide fragment of oxytocin that inhibits hypothermic tolerance induced by ethanol and analgesic and hypothermic tolerance induced by morphine; these effects may be dopamine-dependent.
Product Info
| Purity | ≥95% |
|---|---|
| Formula | C19H26N2O5 |
| Formula Wt. | 362.4 |
| Synonym | Z-P-D-L |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Szabó G, Kovács GL, Székeli S, et al. C-terminal fragments of oxytocin (prolyl-leucyl-glycinamide and Z-prolyl-D-leucine) attenuate the development of tolerance to ethanol. Acta Physiol Hung. 1987;69(1):115-22. PMID: 2884803.
Kovács GL, Izbéki F, Horváth Z, et al. Effects of oxytocin and a derivative (Z-prolyl-D-leucine) on morphine tolerance/withdrawal are mediated by the limbic system. Behav Brain Res. 1984 Oct;14(1):1-8. PMID: 6542796.
Walter R, Ritzmann RF, Bhargava HN, et al. Inhibition by Z-Pro-D-Leu of development of tolerance to and physical dependence on morphine in mice. Proc Natl Acad Sci U S A. 1978 Sep;75(9):4573-6. PMID: 279936.