• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Zileuton

Zileuton

Product ID Z3444
Cas No. 111406-87-2
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $125.80 In stock
250 mg $251.50 In stock
1 g $503.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Zileuton is an inhibitor of 5-lipoxygenase that exhibits anti-inflammatory, anti-asthma, anti-allergic, neuroprotective, cognition enhancing, anti-metastatic, and anticancer chemotherapeutic activities. In vitro and in vivo, zileuton inhibits release of arachidonic acid, inhibiting production of inflammatory mediators such as prostaglandins. Zileuton inhibits hyperplasia, hypertrophy, and remodeling of the extracellular matrix in animal models of chronic asthma and is thought to act through a PI3K/Akt-mediated pathway. In an animal model of cerebral ischemia/reperfusion using middle cerebral artery occlusion, zileuton inhibited increases in caspases 1 and 3, preventing neuronal apoptosis. Zileuton also displays some benefit in animal models of Alzheimer’s disease, decreasing amyloid-β (Aβ) levels and deposition, downregulating signaling by γ-secretase and phosphorylation of tau protein, and improving memory deficits.

Product Info

Cas No.

111406-87-2

Purity

≥98%

Formula

C11H12N2O2S

Formula Wt.

236.29

Chemical Name

1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea

IUPAC Name

1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea

Melting Point

144.2-145.2°C

Solubility

>0.5 mg/ml in DMSO:PBS (pH 7.2) (1:1)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

Z3444 MSDS PDF

Info Sheet

Z3444 Info Sheet PDF

References

Meng Z, Cao R, Yang Z, et al. Inhibitor of 5-Lipoxygenase, Zileuton, Suppresses Prostate Cancer Metastasis by Upregulating E-cadherin and Paxillin. Urology. 2013 Dec;82(6):1452.e7-1452.e14. PMID: 24295266.

Chen WJ, Liaw SF, Lin CC, et al. Effects of zileuton on airway smooth muscle remodeling after repeated allergen challenge in brown norway rats. Respiration. 2013;86(5):421-9. PMID: 24021192.

Shi SS, Yang WZ, Tu XK, et al. 5-Lipoxygenase inhibitor zileuton inhibits neuronal apoptosis following focal cerebral ischemia. Inflammation. 2013 Dec;36(6):1209-17. PMID: 23695166

Chu J, Li JG, Praticò D. Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles. PLoS One. 2013 Aug 7;8(8):e70991. PMID: 23951061.

Chu J, Praticò D. 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5. Neurobiol Aging. 2013 Jun;34(6):1549-54. PMID: 23332172.

Rossi A, Pergola C, Koeberle A, et al. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages. Br J Pharmacol. 2010 Oct;161(3):555-70. PMID: 20880396.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • F285081

    Fidaxomicin

    Macrocycle

    ≥98%
  • H9861

    Hypericin

    Naphthodianthrone found in Hypericum; dopamine ...

    ≥98%
  • C1869

    Cerulenin

    Found in Cephalosporium; fatty acid synthase in...

    ≥98%
  • N5655

    Nonoxynol-9

    Nonoxynol surfactant.

    90-110%
  • A2046

    Aflatoxin B2

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • S0500

    SB-203580

    p38 MAPK inhibitor.

    ≥98%
  • V3213

    Vidarabine Monophosphate

    Nucleoside (adenosine) analog found in Tethyra ...

    ≥98.0%
  • O9334

    Oxibendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • T8145

    Tulobuterol Hydrochloride

    β2-adrenergic agonist.

    ≥98%
  • P200099

    PF-06939999

    PRMT5 inhibitor

    ≥98%
  • T1016

    Propyl Analog of Paclitaxel

    Fermentation impurity

    ≥95%
  • R1779

    13-cis-Retinoic Acid

    Vitamin A metabolite, differentiation inducer; ...

    97%
  • F1670

    Ferulic Acid Methyl Ester

    Hydroxycinnamic aicd, verbascoside metabolite, ...

    ≥98%
  • E5369

    Enrofloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • M568264

    Mogroside IIe

    Triterpenoid

    ≥98%
  • T5871

    Torin 2

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibi...

    ≥98%
  • A6058

    Apoptosis Activator 2

    Apoptosis inducing agent.

    ≥98%
  • E7758

    Etomidate

    GABA-A agonist.

    ≥99%
  • G124084

    GDC-0973

    MEK1 inhibitor.

    ≥99%
  • A4850

    [His18]-Amylin, rat

    Endogenous peptide hormone inolved in gastric e...

    ≥95%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only