• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Zileuton

Zileuton

Product ID Z3444
Cas No. 111406-87-2
Purity ≥98%
Product Unit SizeCostQuantityStock
100 mg $125.80 In stock
250 mg $251.50 In stock
1 g $503.40 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Zileuton is an inhibitor of 5-lipoxygenase that exhibits anti-inflammatory, anti-asthma, anti-allergic, neuroprotective, cognition enhancing, anti-metastatic, and anticancer chemotherapeutic activities. In vitro and in vivo, zileuton inhibits release of arachidonic acid, inhibiting production of inflammatory mediators such as prostaglandins. Zileuton inhibits hyperplasia, hypertrophy, and remodeling of the extracellular matrix in animal models of chronic asthma and is thought to act through a PI3K/Akt-mediated pathway. In an animal model of cerebral ischemia/reperfusion using middle cerebral artery occlusion, zileuton inhibited increases in caspases 1 and 3, preventing neuronal apoptosis. Zileuton also displays some benefit in animal models of Alzheimer’s disease, decreasing amyloid-β (Aβ) levels and deposition, downregulating signaling by γ-secretase and phosphorylation of tau protein, and improving memory deficits.

Product Info

Cas No.

111406-87-2

Purity

≥98%

Formula

C11H12N2O2S

Formula Wt.

236.29

Chemical Name

1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea

IUPAC Name

1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea

Melting Point

144.2-145.2°C

Solubility

>0.5 mg/ml in DMSO:PBS (pH 7.2) (1:1)

Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

Z3444 MSDS PDF

Info Sheet

Z3444 Info Sheet PDF

References

Meng Z, Cao R, Yang Z, et al. Inhibitor of 5-Lipoxygenase, Zileuton, Suppresses Prostate Cancer Metastasis by Upregulating E-cadherin and Paxillin. Urology. 2013 Dec;82(6):1452.e7-1452.e14. PMID: 24295266.

Chen WJ, Liaw SF, Lin CC, et al. Effects of zileuton on airway smooth muscle remodeling after repeated allergen challenge in brown norway rats. Respiration. 2013;86(5):421-9. PMID: 24021192.

Shi SS, Yang WZ, Tu XK, et al. 5-Lipoxygenase inhibitor zileuton inhibits neuronal apoptosis following focal cerebral ischemia. Inflammation. 2013 Dec;36(6):1209-17. PMID: 23695166

Chu J, Li JG, Praticò D. Zileuton improves memory deficits, amyloid and tau pathology in a mouse model of Alzheimer's disease with plaques and tangles. PLoS One. 2013 Aug 7;8(8):e70991. PMID: 23951061.

Chu J, Praticò D. 5-Lipoxygenase pharmacological blockade decreases tau phosphorylation in vivo: involvement of the cyclin-dependent kinase-5. Neurobiol Aging. 2013 Jun;34(6):1549-54. PMID: 23332172.

Rossi A, Pergola C, Koeberle A, et al. The 5-lipoxygenase inhibitor, zileuton, suppresses prostaglandin biosynthesis by inhibition of arachidonic acid release in macrophages. Br J Pharmacol. 2010 Oct;161(3):555-70. PMID: 20880396.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T5870

    Torin 1

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibi...

    ≥98%
  • E5216

    β-Endorphin, camel

    Endogenous opioid peptide; μOR agonist.

    ≥95%
  • A4849

    Amyloid-β (25-35)

    Endogenous APP peptide cleavage product, primar...

    ≥95%
  • A4847

    Amylin, human

    Endogenous peptide hormone inolved in gastric e...

    ≥95%
  • D3201

    Diallyl Sulfide

    Organosulfur found in garlic.

    ≥98%
  • P2508

    Phenethyl Isothiocyanate

    ITC found in cruciferous vegetables.

    ≥99%
  • A4930

    7-Aminoactinomycin D

    Actinomycin derivative used to study apoptosis ...

    ≥98%
  • D1995

    Dexrazoxane Hydrochloride

    Iron chelator.

    ≥98%
  • I7658

    1-Isothiocyanato-9-(methylsulfonyl)-nonane

    Synthetic ITC, erysolin analog.

    ≥98%
  • F5770

    Formononetin

    Isoflavone found in legumes such as soy.

    ≥90%
  • G5216

    GNE-7915

    LRRK2 inhibitor.

    ≥98%
  • A9812

    AZD-1480

    JAK1/2 inhibitor.

    ≥98%
  • K1776

    Ketotifen Fumarate

    H1 histamine and LT antagonist, PDE inhibitor.<...

    ≥98%
  • T1853

    Tenovin-6

    SIRT1/2 inhibitor, indirect p53 activator.

    ≥98%
  • H9802

    Hyaluronic Acid Sodium (7-10 kDA)

    Glycosaminoglycan

  • P2512

    S-(N-Phenethylthiocarbamoyl)-L-cysteine

    Cysteine-ITC conjugate, antioxidant.

    ≥98%
  • N582686

    L-(-)-Norepinephrine-(+)-bitartrate

    Endogenous hormone and neurotransmitter involve...

    ≥98%
  • R1626

    Regorafenib Monohydrate

    VEGFR1/2/3, TIE2, PDGFRβ, FGFR1, c-Kit, RET, B...

    ≥99%
  • T0081

    Taurine

    Endogenous sulfonic acid involved in Ca2+ signa...

    ≥99%
  • G3456

    Ginsenoside Rd

    Triterpene saponin found in species of Panax; 2...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only