LKT Labs

Biochemicals for Life Science Research

Nicergoline

Nicergoline

Product ID N3210
Cas No. 27848-84-6
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $97.20 In stock
500 mg $174.90 In stock
1 g $291.60 In stock
Bulk Quote

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Description

Nicergoline is an ergot derivative from the fungi genus Claviceps. Nicergoline exhibits anti-atherosclerotic and antithrombotic activity, used to treat vascular disorders including thrombosis, atherosclerosis, Reynaud’s disease, and retinopathy. This compound acts as an α1-adrenergic receptor inhibitor and also inhibits platelet aggregation. Additionally, nicergoline shows neuroprotective benefit, increasing glutamate uptake and levels of BDNF and substance P in the brain. Nicergoline also decreases levels of pro-inflammatory cytokines TNF-α, IL-6, and IL-1β.

Product Info

Cas No.

27848-84-6
Purity

≥98%
Formula

C24H26BrN3O3
Formula Wt.

484.39
Chemical Name

5-Bromonicotinic acid 10-methoxy-1,6-dimethylergoline-8-methyl ester
IUPAC Name

[(6aR,9R,10aS)-10a-methoxy-4,7-dimethyl-6a,8,9,10-tetrahydro-6H-indolo[4,3-fg]quinoline-9-yl]methyl 5-bromopyridine-3-carboxylate
Synonym

Nicotergoline; Nimergoline; Nimergoline base; Nicergolinum
Solubility

soluble in DMSO; alcohol, chloroform, and acetone

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

N3210 MSDS PDF
Info Sheet

N3210 Info Sheet PDF

References

Nishiyama Y, Abe A, Ueda M, et al. Nicergoline increases serum substance P levels in patients with an ischaemic stroke. Cerebrovasc Dis. 2010 Jan;29(2):194-8. PMID: 20029189.

Schardl CL, Panaccione DG, Tudzynski P. Ergot alkaloids--biology and molecular biology. Alkaloids Chem Biol. 2006;63:45-86. PMID: 17133714.

Mizuno T, Kuno R, Nitta A, et al. Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes. Brain Res. 2005 Dec 20;1066(1-2):78-85. PMID: 16325157.

Nishida A, Iwata H, Kudo Y, et al. Nicergoline enhances glutamate uptake via glutamate transporters in rat cortical synaptosomes. Biol Pharm Bull. 2004 Jun;27(6):817-20. PMID: 15187425.

Fioravanti M, Flicker L. Efficacy of nicergoline in dementia and other age associated forms of cognitive impairment. Cochrane Database Syst Rev. 2001;(4):CD003159. PMID: 11687175.

Alvarez-Guerra M, Bertholom N, Garay RP. Selective blockade by nicergoline of vascular responses elicited by stimulation of alpha 1A-adrenoceptor subtype in the rat. Fundam Clin Pharmacol. 1999;13(1):50-8. PMID: 10027088.

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