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Taxinin M

Taxinin M

Product ID T0114
Cas No. 135730-55-1
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $674.60 In stock
10 mg $1,076.60 In stock
25 mg $2,016.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Taxinine M is a taxane compound originally found in species of the yew tree under the Taxus genus. Taxinines inhibit DNA polymerase. Taxinine M displays anticancer activity, inhibiting lung cancer cell proliferation. Like other taxanes, taxinine M may also promote microtubule polymerization and prevent microtubule depolymerization. However, in tests on human epidermoid carcinoma KB cells, taxinin M showed little or no effect.

Product Info

Cas No.

135730-55-1

Purity

≥98%

Formula

C35H42NO14

Formula Wt.

686.7

Chemical Name

Taxinin M

IUPAC Name

[(1R,2R,3S,4R,5R,6S,8S,10R,11R,12R,15S)-3,4,6,11-tetraacetyloxy-2,8-dihydroxy-1,15-dimethyl-9-methylidene-14-oxo-16-oxatetracyclo[10.5.0.02,15.05,10]heptadecan-5-yl]methyl benzoate

Synonym

Taxinine M

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T0114 MSDS PDF

Info Sheet

T0114 Info Sheet PDF

References

Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.

Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.

Prasain JK, Stefanowicz P, Kiyota T, et al. Taxines from the needles of Taxus wallichiana. Phytochemistry. 2001 Dec;58(8):1167-70. PMID: 11738401.

Kobayashi J, Shigemori H, Hosoyama H, et al. Multidrug resistance reversal activity of taxoids from Taxus cuspidata in MB-C2 and 2780AD cells. Jpn J Cancer Res. 2000 Jun;91(6):638-642. PMID: 10874217.

Beutler JA, Chmurny GM, Look SA, et al. Taxinine M, a new tetracyclic taxane from Taxus brevifolia. J Nat Prod. 1991 May-Jun;54(3):893-7. PMID: 1955887.

Custom Order

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