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Dantrolene is a hydantoin derivative that inhibits the ryanodine receptor (RyR), preventing mitochondrial Ca2+ uptake. Dantrolene also inhibits L-type Ca(V)1.1 Ca2+ channels and is clinically used to treat malignant hyperthermia. Dantrolene also exhibits cardioprotective activity, decreases apoptosis and TNF-α levels and increases IL-10 levels in various animal models of ischemia/reperfusion.
| Cas No. | 24868-20-0 |
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| Purity | ≥98% |
| Formula | (C14H9N4O5Na)2 • 7H2O |
| Formula Wt. | 399.29 |
| Chemical Name | 1-[[[5-(4-Nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione sodium |
| IUPAC Name | sodium;3-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-5-oxo-4H- imidazol-2-olate |
| Synonym | Dantamacrin, Dantrium, F-440, Dantrolene, Sodium Salt Hemiheptahydrate |
| Melting Point | 279-280°C |
| Solubility | Slightly soluble in water; more soluble in alkaline soln. |
| Appearance | Yellowish-Orange to Orange Crystalline Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Jakob R, Beutner G, Sharma VK, et al. Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett. 2014 May 23. [Epub ahead of print]. PMID: 24861510.
Bannister RA. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. Biomed Res Int. 2013;2013:390493. PMID: 23509717.
Boys JA, Toledo AH, Anaya-Prado R, et al. Effects of dantrolene on ischemia-reperfusion injury in animal models: a review of outcomes in heart, brain, liver, and kidney. J Investig Med. 2010 Oct;58(7):875-82. PMID: 20517166.