Obatoclax

Name: Obatoclax
SKU: O0400
Availability: InStock

Product ID O0400

Cas No. 803712-67-6

Purity ≥98%

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Description

Obatoclax is a BH3 mimetic and inhibitor of Bcl-2 and Bcl-xl that displays anti-metastatic and anticancer chemotherapeutic activities; it is currently in clinical trials as a potential treatment for various cancers. Obatoclax induces autophagy and apoptosis in adenoid cystic carcinoma cells and decreases tumor formation and growth in animal models of hepatoblastoma. In cellular models of colorectal cancer, obatoclax inhibits cell growth, induces G1 phase cell cycle arrest, and suppresses proliferation, migration, and invasion.

Product Info

Cas No.	803712-67-6
Purity	≥98%
Formula	C₂₀H₁₉N₃O
Formula Wt.	317.38
IUPAC Name	2-{(2Z)-2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-3-methoxy-2H-pyrrol-5-yl}-1H-indole
Synonym	GX15-070
Solubility	DMSO 83 mg/mL (200.73 mM) Water Insoluble Ethanol Insoluble
Appearance	Darkish green powder

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	O0400 MSDS PDF
Info Sheet	O0400 Info Sheet PDF

References

Liang LZ, Ma B, Liang YJ, et al. Obatoclax induces Beclin 1- and ATG5-dependent apoptosis and autophagy in adenoid cystic carcinoma cells. Oral Dis. 2014 Dec 8. [Epub ahead of print]. PMID: 25482163.

Arellano ML, Borthakur G, Berger M, et al. A phase II, multicenter, open-label study of obatoclax mesylate in patients with previously untreated myelodysplastic syndromes with anemia or thrombocytopenia. Clin Lymphoma Myeloma Leuk. 2014 Dec;14(6):534-9. PMID: 25052051.

Koehler BC, Scherr AL, Lorenz S, et al. Pan-Bcl-2 inhibitor obatoclax delays cell cycle progression and blocks migration of colorectal cancer cells. PLoS One. 2014 Sep 5;9(9):e106571. PMID: 25192188.

Lieber J, Ellerkamp V, Vogt F, et al. BH3-mimetic drugs prevent tumour onset in an orthotopic mouse model of hepatoblastoma. Exp Cell Res. 2014 Mar 10;322(1):217-25. PMID: 24355809.

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Obatoclax

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Product Info

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