LKT Labs

Biochemicals for Life Science Research

Bestatin Hydrochloride

Bestatin Hydrochloride

Product ID B1874
Cas No. 65391-42-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $61.10 In stock
5 mg $100.20 In stock
10 mg $188.00 In stock
25 mg $357.30 In stock
Bulk Quote

Quicklinks

Description

Bestatin is a dipeptide inhibitor of aminopeptidases such as aminopeptidase N/CD13. Bestatin displays efficacy in the treatment of lung cancer. This compound exhibits anticancer chemotherapeutic, immunomodulatory, and analgesic activities. Bestatin enhances differentiation of acute promyelocytic leukemia (APL) cells. Additionally, bestatin enhances proliferation of bone marrow macrophage progenitor cells and formation of CFU-GM colonies. This compound also inhibits catabolism of opioid endopeptides.

Product Info

Cas No.

65391-42-6
Purity

≥98%
Formula

C16H24N2O4 • HCl
Formula Wt.

344.87
Chemical Name

N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutyl]-L-leucine hydrochloride
IUPAC Name

(2S)-2-[[(2S, 3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid;hydrochloride
Synonym

Ubenimex hydrochloride
Melting Point

216-218°C
Solubility

Soluble in water (25mg.mL).
Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

B1874 MSDS PDF
Info Sheet

B1874 Info Sheet PDF

References

Hitzerd SM, Verbrugge SE, Ossenkoppele G, et al. Positioning of aminopeptidase inhibitors in next generation cancer therapy. Amino Acids. 2014 Apr;46(4):793-808. PMID: 24385243.

Qian X, He J, Zhao Y, et al. Inhibition of p38 MAPK Phosphorylation Is Critical for Bestatin to Enhance ATRA-Induced Cell Differentiation in Acute Promyelocytic Leukemia NB4 Cells. Am J Ther. 2013 Oct 17. [Epub ahead of print]. PMID: 24141198.

Jia MR, Wei T, Xu WF. The Analgesic Activity of Bestatin as a Potent APN Inhibitor. Front Neurosci. 2010 Jun 28;4:50. PMID: 20631848.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4440

    Allicin

    Organosulfur found in garlic, binds DNA; inward...

    ≥98%
  • M174446

    Meleagrin

    FabI inhibitor

    ≥99%
  • L960010

    LY-3200882

    TGF-β1 inhibitor.

    ≥98%
  • B6806

    Bradykinin (2-9)

    Natriuretic, vasodilatory peptide fragment; B1/...

    ≥95%
  • B564086

    Boceprevir

    Inhibits HCV replication

    ≥98%
  • B1973

    Besifloxacin Hydrochloride

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%
  • C2956

    Cholecalciferol

    Endogenous vitamin D prodrug.

    ≥98%
  • T3041

    Thienylpropyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥98%
  • P200099

    PF-06939999

    PRMT5 inhibitor

    ≥98%
  • P327212

    Pifithrin-α-cyclic Hydrobromide

    p53 inhibitor

    ≥98%
  • T6817

    D(+)-Trehalose Dihydrate

    α-Linked disaccharide composed of α-glucose u...

    ≥98%
  • T1852

    Tenovin-1

    SIRT1/2 inhibitor, indirect p53 activator.

    ≥98%
  • N344780

    N-Nitroso Bumetanide

    Bumetanide impurity

    ≥99%
  • Q8134

    Quinapril Hydrochloride

    ACE inhibitor.

    ≥98%
  • C9613

    Cyclosporin D

    Cyclosporin metabolite; weak calmodulin inhibit...

    ≥98%
  • A528251

    Angiotensin I/II (1-7)(DP-7)

    Peptide fragment

    ≥95%
  • A9662

    AZ-628

    B-Raf and c-Raf inhibitor.

    ≥96%
  • M5793

    Moxifloxacin Free Base

    Fluoroquinolone; topoisomerase IV, topoisomeras...

    ≥98%
  • T7133

    Trimetazidine Dihydrochloride

    Long-chain 3-ketoacyl-CoA thiolase inhibitor, p...

    ≥99%
  • E5221

    Endothelin-2, human

    Endogenous peptide involved in vascular contrac...

    ≥95%